# Query = Query compound # SE ID = ID of side effect # SE Name = Name of side effect # SVM Prob = Probability estimation by support vector machine # SVM Pred = Predict estimation by support vector machine # RF Prob = Probability estimation by random forest # RF Pred = Predict estimation by random forest # Possibility = Probability of side effects Query SE ID SE Name SVM Prob SVM Pred RF Prob RF Pred Possibility Caffeine C0027497 Nausea 1.0 1 1.0 1 High Caffeine C0018681 Headache 1.0 1 0.998 1 High Caffeine C0015230 Rash 1.0 1 0.996 1 High Caffeine C0011603 Dermatitis 1.0 1 0.996 1 High Caffeine C0009806 Constipation 1.0 1 0.991 1 High Caffeine C0042963 Vomiting 1.0 1 0.991 1 High Caffeine C0020649 Hypotension 1.0 1 0.985 1 High Caffeine C0013404 Dyspnoea 1.0 1 0.953 1 High Caffeine C0040034 Thrombocytopenia 1.0 1 0.946 1 High Caffeine C0085593 Chills 1.0 1 0.932 1 High Caffeine C0013378 Dysgeusia 1.0 1 0.92 1 High Caffeine C0023530 Leukopenia 1.0 1 0.91 1 High Caffeine C0012833 Dizziness 0.997 1 1.0 1 High Caffeine C0004093 Asthenia 0.997 1 0.997 1 High Caffeine C0011991 Diarrhoea 0.997 1 0.987 1 High Caffeine C0000731 Abdominal distension 0.997 1 0.929 1 High Caffeine C0521839 Influenza like illness 0.997 1 0.881 1 High Caffeine C0039231 Tachycardia 0.997 1 0.874 1 High Caffeine C0687713 Gastrointestinal pain 0.996 1 0.999 1 High Caffeine C0000737 Abdominal pain 0.996 1 0.998 1 High Caffeine C0033774 Pruritus 0.996 1 0.977 1 High Caffeine C0037763 Muscle spasms 0.996 1 0.954 1 High Caffeine C0232462 Decreased appetite 0.996 1 0.935 1 High Caffeine C0023380 Lethargy 0.996 1 0.841 1 High Caffeine C0016204 Flatulence 0.996 1 0.793 1 High Caffeine C0027424 Nasal congestion 0.995 1 0.949 1 High Caffeine C0038362 Stomatitis 0.995 1 0.917 1 High Caffeine C0030554 Paraesthesia 0.995 1 0.913 1 High Caffeine C0002871 Anaemia 0.995 1 0.9 1 High Caffeine C0232487 Abdominal discomfort 0.995 1 0.803 1 High Caffeine C0013395 Dyspepsia 0.994 1 0.962 1 High Caffeine C0040822 Tremor 0.994 1 0.888 1 High Caffeine C0392171 Influenza-like symptoms 0.994 1 0.811 1 High Caffeine C0013428 Dysuria 0.994 1 0.71 1 High Caffeine C0015967 Body temperature increased 0.993 1 0.941 1 High Caffeine C0002170 Alopecia 0.993 1 0.85 1 High Caffeine C0013491 Ecchymosis 0.993 1 0.802 1 High Caffeine C0042109 Urticaria 0.992 1 0.882 1 High Caffeine C0003123 Anorexia 0.991 1 0.922 1 High Caffeine C0032285 Pneumonia 0.991 1 0.914 1 High Caffeine C0036974 Shock 0.991 1 0.893 1 High Caffeine C0011570 Depression 0.991 1 0.884 1 High Caffeine C0042023 Pollakiuria 0.991 1 0.787 1 High Caffeine C0041657 Loss of consciousness 0.99 1 0.884 1 High Caffeine C0039070 Syncope 0.99 1 0.884 1 High Caffeine C0013604 Oedema 0.99 1 0.88 1 High Caffeine C0030193 Pain 0.989 1 0.954 1 High Caffeine C0344232 Vision blurred 0.989 1 0.93 1 High Caffeine C0006277 Bronchitis 0.989 1 0.871 1 High Caffeine C0011175 Dehydration 0.989 1 0.79 1 High Caffeine C0017178 Gastrointestinal disorder 0.988 1 0.926 1 High Caffeine C0003467 Anxiety 0.988 1 0.891 1 High Caffeine C0233472 Affect lability 0.987 1 0.898 1 High Caffeine C0030252 Palpitations 0.987 1 0.886 1 High Caffeine C0085649 Oedema peripheral 0.987 1 0.866 1 High Caffeine C0002622 Amnesia 0.987 1 0.855 1 High Caffeine C0851578 Sleep disorder 0.987 1 0.854 1 High Caffeine C0014591 Epistaxis 0.987 1 0.84 1 High Caffeine C0020580 Hypoaesthesia 0.987 1 0.821 1 High Caffeine C0008031 Chest pain 0.986 1 0.939 1 High Caffeine C0009676 Confusional state 0.986 1 0.909 1 High Caffeine C0026821 Cramp muscle 0.986 1 0.907 1 High Caffeine C0085631 Agitation 0.986 1 0.887 1 High Caffeine C0149931 Migraine 0.986 1 0.806 1 High Caffeine C0009763 Conjunctivitis 0.986 1 0.758 1 High Caffeine C0043096 Weight decreased 0.985 1 0.893 1 High Caffeine C0917801 Insomnia 0.984 1 0.939 1 High Caffeine C0085633 Mood swings 0.984 1 0.895 1 High Caffeine C0151905 Alanine aminotransferase increased 0.983 1 0.839 1 High Caffeine C0151735 Injection site reaction 0.983 1 0.814 1 High Caffeine C0151786 Muscular weakness 0.983 1 0.802 1 High Caffeine C2830004 Somnolence 0.982 1 0.877 1 High Caffeine C0020456 Hyperglycaemia 0.982 1 0.859 1 High Caffeine C0016382 Flushing 0.982 1 0.848 1 High Caffeine C0035455 Rhinitis 0.982 1 0.843 1 High Caffeine C0151908 Dry skin 0.982 1 0.781 1 High Caffeine C0041912 Upper respiratory tract infection 0.981 1 0.897 1 High Caffeine C0029408 Osteoarthritis 0.981 1 0.886 1 High Caffeine C0022107 Irritability 0.981 1 0.771 1 High Caffeine C0012569 Diplopia 0.981 1 0.769 1 High Caffeine C0041834 Erythema 0.98 1 0.821 1 High Caffeine C0040264 Tinnitus 0.98 1 0.741 1 High Caffeine C0036572 Convulsion 0.979 1 0.755 1 High Caffeine C0020621 Hypokalaemia 0.979 1 0.739 1 High Caffeine C0004604 Back pain 0.978 1 0.983 1 High Caffeine C0020538 Hypertension 0.978 1 0.934 1 High Caffeine C0017160 Gastroenteritis 0.978 1 0.814 1 High Caffeine C0428977 Bradycardia 0.978 1 0.749 1 High Caffeine C0013390 Dysmenorrhoea 0.977 1 0.744 1 High Caffeine C0043352 Dry mouth 0.976 1 0.846 1 High Caffeine C0013595 Eczema 0.975 1 0.886 1 High Caffeine C0030196 Pain in extremity 0.974 1 0.865 1 High Caffeine C0151828 Injection site pain 0.974 1 0.608 1 High Caffeine C0020458 Hyperhidrosis 0.973 1 0.832 1 High Caffeine C0009450 Infection 0.972 1 0.903 1 High Caffeine C0018965 Haematuria 0.972 1 0.855 1 High Caffeine C0542571 Face oedema 0.97 1 0.831 1 High Caffeine C0002418 Amblyopia 0.97 1 0.819 1 High Caffeine C2363731 Oropharyngeal pain 0.97 1 0.778 1 High Caffeine C0011168 Dysphagia 0.97 1 0.761 1 High Caffeine C3263723 Injury 0.969 1 0.846 1 High Caffeine C0042769 Viral infection 0.969 1 0.748 1 High Caffeine C0042571 Vertigo 0.968 1 0.864 1 High Caffeine C0233414 Disturbance in attention 0.968 1 0.792 1 High Caffeine C0009938 Contusion 0.968 1 0.79 1 High Caffeine C0020615 Hypoglycaemia 0.968 1 0.769 1 High Caffeine C0004134 Ataxia 0.967 1 0.842 1 High Caffeine C0231530 Muscle twitching 0.967 1 0.78 1 High Caffeine C1443060 Feeling abnormal 0.966 1 0.877 1 High Caffeine C1306341 Mental disability 0.966 1 0.813 1 High Caffeine C0220870 Lightheadedness 0.966 1 0.773 1 High Caffeine C0015672 Fatigue 0.965 1 0.976 1 High Caffeine C0231528 Myalgia 0.965 1 0.931 1 High Caffeine C0035243 Respiratory tract infection 0.965 1 0.828 1 High Caffeine C0020517 Hypersensitivity 0.964 1 0.855 1 High Caffeine C3665347 Visual impairment 0.964 1 0.824 1 High Caffeine C0037274 Skin disorder 0.964 1 0.787 1 High Caffeine C0017152 Gastritis 0.964 1 0.765 1 High Caffeine C0518015 Haemoglobin 0.962 1 0.821 1 High Caffeine C0019080 Haemorrhage 0.962 1 0.821 1 High Caffeine C0042029 Urinary tract infection 0.96 1 0.885 1 High Caffeine C0027441 Nasopharyngitis 0.959 1 0.888 1 High Caffeine C1260880 Rhinorrhoea 0.959 1 0.694 1 High Caffeine C0575090 Balance disorder 0.959 1 0.626 1 High Caffeine C0043094 Weight increased 0.958 1 0.685 1 High Caffeine C0232461 Increased appetite 0.957 1 0.825 1 High Caffeine C0702166 Acne 0.957 1 0.691 1 High Caffeine C0027769 Nervousness 0.955 1 0.829 1 High Caffeine C0018524 Hallucination 0.955 1 0.661 1 High Caffeine C0007859 Neck pain 0.954 1 0.878 1 High Caffeine C0028738 Nystagmus 0.954 1 0.734 1 High Caffeine C0027947 Neutropenia 0.953 1 0.649 1 High Caffeine C0575081 Gait disturbance 0.952 1 0.801 1 High Caffeine C0234215 Discomfort 0.952 1 0.793 1 High Caffeine C0520966 Coordination abnormal 0.952 1 0.752 1 High Caffeine C0037199 Sinusitis 0.951 1 0.908 1 High Caffeine C0233494 Tension 0.951 1 0.834 1 High Caffeine C0151723 Hypomagnesaemia 0.951 1 0.68 1 High Caffeine C0042373 Angiopathy 0.95 1 0.803 1 High Caffeine C0013144 Drowsiness 0.95 1 0.757 1 High Caffeine C0151904 Aspartate aminotransferase increased 0.949 1 0.838 1 High Caffeine C0424790 Rigors 0.949 1 0.725 1 High Caffeine C0151766 Liver function test abnormal 0.949 1 0.715 1 High Caffeine C0017168 Gastrooesophageal reflux disease 0.945 1 0.685 1 High Caffeine C3665386 Abnormal vision 0.943 1 0.819 1 High Caffeine C0006840 Candida infection 0.941 1 0.786 1 High Caffeine C0242350 Erectile dysfunction 0.94 1 0.912 1 High Caffeine C0178298 Unspecified disorder of skin and subcutaneous tissue 0.937 1 0.79 1 High Caffeine C0404521 Vaginal infection 0.936 1 0.769 1 High Caffeine C0035078 Renal failure 0.935 1 0.651 1 High Caffeine C0700590 Sweating increased 0.934 1 0.84 1 High Caffeine C0042267 Vaginal inflammation 0.934 1 0.742 1 High Caffeine C0001807 Aggression 0.934 1 0.588 1 High Caffeine C0233632 Thinking abnormal 0.933 1 0.825 1 High Caffeine C0948594 Musculoskeletal discomfort 0.932 1 0.903 1 High Caffeine C0010200 Cough 0.931 1 0.943 1 High Caffeine C0151849 Phosphatase alkaline increased 0.928 1 0.648 1 High Caffeine C0034150 Purpura 0.927 1 0.654 1 High Caffeine C0852911 Blood alkaline phosphatase increased 0.927 1 0.591 1 High Caffeine C1368065 Vascular purpura 0.924 1 0.642 1 High Caffeine C0013362 Dysarthria 0.922 1 0.715 1 High Caffeine C0022408 Arthropathy 0.922 1 0.668 1 High Caffeine C0151736 Accidental injury 0.92 1 0.829 1 High Caffeine C0023218 Cramps of lower extremities 0.92 1 0.77 1 High Caffeine C0600142 Hot flush 0.916 1 0.762 1 High Caffeine C0236075 Menopausal symptoms 0.916 1 0.762 1 High Caffeine C0020625 Hyponatraemia 0.913 1 0.664 1 High Caffeine C0037822 Speech disorder 0.913 1 0.615 1 High Caffeine C0151662 Gamma-glutamyltransferase increased 0.912 1 0.682 1 High Caffeine C0162429 Malnutrition 0.909 1 0.569 1 High Caffeine C0038990 Sweating 0.907 1 0.887 1 High Caffeine C0085682 Hypophosphataemia 0.906 1 0.666 1 High Caffeine C0042075 Urinary tract disorder 0.905 1 0.543 1 High Caffeine C0041969 Urethral disorder 0.905 1 0.543 1 High Caffeine C0042024 Urinary incontinence 0.903 1 0.71 1 High Caffeine C0004096 Asthma 0.901 1 0.641 1 High Caffeine C0003862 Arthralgia 0.898 1 0.844 1 High Caffeine C0004238 Atrial fibrillation 0.896 1 0.642 1 High Caffeine C0039971 Thirst 0.895 1 0.702 1 High Caffeine C0031350 Pharyngitis 0.893 1 0.804 1 High Caffeine C0549249 Depressed level of consciousness 0.893 1 0.581 1 High Caffeine C0003811 Arrhythmia 0.892 1 0.701 1 High Caffeine C0037299 Skin ulcer 0.892 1 0.608 1 High Caffeine C0314719 Dry eye 0.889 1 0.636 1 High Caffeine C0677500 Stinging 0.885 1 0.663 1 High Caffeine C0080274 Urinary retention 0.881 1 0.653 1 High Caffeine C0018802 Cardiac failure congestive 0.881 1 0.543 1 High Caffeine C0040435 Tooth disorder 0.88 1 0.804 1 High Caffeine C0235431 Blood creatinine increased 0.879 1 0.7 1 High Caffeine C0151827 Eye pain 0.876 1 0.632 1 High Caffeine C0547030 Visual disturbance 0.875 1 0.702 1 High Caffeine C0015397 Eye disorder 0.873 1 0.572 1 High Caffeine C0549373 Laryngeal pain 0.872 1 0.655 1 High Caffeine C0858635 Pharyngolaryngeal pain 0.872 1 0.655 1 High Caffeine C0020676 Hypothyroidism 0.87 1 0.567 1 High Caffeine C2047937 Ill-defined disorder 0.869 1 0.778 1 High Caffeine C0002962 Angina pectoris 0.868 1 0.637 1 High Caffeine C0025061 Mediastinal disorder 0.868 1 0.567 1 High Caffeine C0019112 Haemorrhoids 0.866 1 0.57 1 High Caffeine C0029882 Otitis media 0.865 1 0.663 1 High Caffeine C0231218 Malaise 0.863 1 0.78 1 High Caffeine C0018801 Cardiac failure 0.863 1 0.671 1 High Caffeine C0014457 Eosinophilia 0.863 1 0.549 1 High Caffeine C0017181 Gastrointestinal haemorrhage 0.861 1 0.831 1 High Caffeine C0021400 Influenza 0.859 1 0.776 1 High Caffeine C0040460 Toothache 0.857 1 0.716 1 High Caffeine C0232492 Abdominal pain upper 0.856 1 0.6 1 High Caffeine C0423791 Rash maculo-papular 0.855 1 0.634 1 High Caffeine C0234233 Tenderness 0.854 1 0.624 1 High Caffeine C0018799 Cardiac disorder 0.853 1 0.649 1 High Caffeine C0233794 Memory impairment 0.853 1 0.624 1 High Caffeine C0026946 Fungal infection 0.851 1 0.695 1 High Caffeine C0031117 Neuropathy peripheral 0.846 1 0.737 1 High Caffeine C0086439 Hypokinesia 0.846 1 0.617 1 High Caffeine C0233407 Disorientation 0.842 1 0.665 1 High Caffeine C0234913 Rash erythematous 0.839 1 0.656 1 High Caffeine C0855242 Disturbance in sexual arousal 0.836 1 0.607 1 High Caffeine C2363730 Oropharyngeal discomfort 0.836 1 0.501 1 High Caffeine C0242429 Throat sore 0.836 1 0.501 1 High Caffeine C0151888 Hyporeflexia 0.828 1 0.516 1 High Caffeine C0947912 Myasthenia 0.825 1 0.665 1 High Caffeine C0020651 Orthostatic hypotension 0.824 1 0.715 1 High Caffeine C0009782 Connective tissue disorder 0.824 1 0.613 1 High Caffeine C0004936 Mental disorder 0.824 1 0.602 1 High Caffeine C1145670 Respiratory failure 0.822 1 0.668 1 High Caffeine C0574067 Cough increased 0.813 1 0.73 1 High Caffeine C0476280 Musculoskeletal chest pain 0.812 1 0.539 1 High Caffeine C0020461 Hyperkalaemia 0.81 1 0.524 1 High Caffeine C0011124 Libido decreased 0.808 1 0.588 1 High Caffeine C0031542 Phlebitis 0.807 1 0.726 1 High Caffeine C0151505 Application site reaction 0.806 1 0.793 1 High Caffeine C0746883 Febrile neutropenia 0.799 1 0.685 1 High Caffeine C0151889 Hyperreflexia 0.798 1 0.507 1 High Caffeine C0011053 Deafness 0.795 1 0.551 1 High Caffeine C0027765 Nervous system disorder 0.794 1 0.76 1 High Caffeine C0007642 Cellulitis 0.793 1 0.645 1 High Caffeine C0043144 Wheezing 0.78 1 0.77 1 High Caffeine C0162830 Photosensitivity reaction 0.78 1 0.579 1 High Caffeine C1565489 Renal impairment 0.776 1 0.592 1 High Caffeine C0948525 Musculoskeletal stiffness 0.776 1 0.528 1 High Caffeine C0740394 Hyperuricaemia 0.773 1 0.676 1 High Caffeine C0151825 Bone pain 0.772 1 0.533 1 High Caffeine C0853619 Local swelling 0.771 1 0.628 1 High Caffeine C0853034 Blood creatine phosphokinase increased 0.769 1 0.681 1 High Caffeine C0020598 Hypocalcaemia 0.769 1 0.529 1 High Caffeine C0151576 Creatine phosphokinase increased 0.762 1 0.526 1 High Caffeine C0030312 Pancytopenia 0.757 1 0.556 1 High Caffeine C0235198 Cerebration impaired 0.753 1 0.646 1 High Caffeine C0497156 Lymphadenopathy 0.751 1 0.533 1 High Caffeine C0038454 Cerebrovascular accident 0.748 1 0.662 1 High Caffeine C0026858 Musculoskeletal pain 0.747 1 0.815 1 High Caffeine C0017574 Gingivitis 0.745 1 0.593 1 High Caffeine C1619712 Procedural pain 0.73 1 0.502 1 High Caffeine C0442874 Neuropathy 0.729 1 0.615 1 High Caffeine C0013384 Dyskinesia 0.726 1 0.502 1 High Caffeine C0152029 Sinus congestion 0.725 1 0.589 1 High Caffeine C0085932 Dermatitis bullous 0.721 1 0.597 1 High Caffeine C0028081 Night sweats 0.72 1 0.628 1 High Caffeine C0005779 Coagulopathy 0.72 1 0.511 1 High Caffeine C0235416 Blood uric acid increased 0.719 1 0.67 1 High Caffeine C0149745 Mouth ulceration 0.719 1 0.585 1 High Caffeine C0243026 Sepsis 0.715 1 0.581 1 High Caffeine C0151578 Creatinine increased 0.71 1 0.676 1 High Caffeine C0027339 Nail disorder 0.7 1 0.609 1 High Caffeine C0002453 Amenorrhoea 0.698 1 0.518 1 High Caffeine C0006849 Oral candidiasis 0.692 1 0.684 1 High Caffeine C0750394 White blood cell count decreased 0.671 1 0.552 1 High Caffeine C0235710 Chest discomfort 0.668 1 0.59 1 High Caffeine C0268000 Fluid retention 0.656 1 0.666 1 High Caffeine C0242184 Hypoxia 0.646 1 0.527 1 High Caffeine C0235309 Upset stomach 0.645 1 0.53 1 High Caffeine Ear and labyrinth disorders 0.631 1 0.561 1 High Caffeine C0003864 Arthritis 0.616 1 0.691 1 High Caffeine C0235146 Euphoric mood 0.61 1 0.531 1 High Caffeine C0024312 Lymphopenia 0.587 1 0.538 1 High Caffeine C0024902 Breast pain 0.566 1 0.586 1 High Caffeine C0032227 Pleural effusion 0.566 1 0.574 1 High Caffeine C0020433 Hyperbilirubinaemia 0.528 1 0.568 1 High Caffeine C0267596 Rectal haemorrhage 0.932 1 0.376 0 Moderate Caffeine C0030232 Pallor 0.862 1 0.455 0 Moderate Caffeine C0851341 Infestation NOS 0.839 1 0.47 0 Moderate Caffeine C1384353 Infestation 0.839 1 0.47 0 Moderate Caffeine C0006266 Bronchospasm 0.812 1 0.33 0 Moderate Caffeine C0013456 Ear pain 0.809 1 0.44 0 Moderate Caffeine C0023222 Leg pain 0.804 1 0.427 0 Moderate Caffeine C0349506 Photosensitivity 0.794 1 0.454 0 Moderate Caffeine C0043251 Trauma 0.778 1 0.465 0 Moderate Caffeine C0234458 Abnormal dreams 0.772 1 0.466 0 Moderate Caffeine C0152227 Lacrimation increased 0.772 1 0.443 0 Moderate Caffeine C0018944 Haematoma 0.761 1 0.382 0 Moderate Caffeine C0085628 Stupor 0.758 1 0.44 0 Moderate Caffeine C0227791 Vaginal discharge 0.756 1 0.412 0 Moderate Caffeine C0025345 Menstrual disorder 0.75 1 0.497 0 Moderate Caffeine C0015732 Faecal incontinence 0.743 1 0.436 0 Moderate Caffeine C0700184 Throat irritation 0.737 1 0.426 0 Moderate Caffeine C0013447 Ear disorder 0.734 1 0.409 0 Moderate Caffeine C0025362 Mental retardation 0.725 1 0.401 0 Moderate Caffeine C0038999 Swelling 0.724 1 0.459 0 Moderate Caffeine C0151539 Blood urea increased 0.707 1 0.483 0 Moderate Caffeine C0037036 Salivary hypersecretion 0.705 1 0.476 0 Moderate Caffeine C0015371 Extrapyramidal disorder 0.701 1 0.375 0 Moderate Caffeine C0031212 Personality disorder 0.699 1 0.469 0 Moderate Caffeine C0026826 Hypertonia 0.699 1 0.466 0 Moderate Caffeine C0232849 Bladder pain 0.69 1 0.4 0 Moderate Caffeine C0014130 Endocrine disorder 0.69 1 0.4 0 Moderate Caffeine C0010692 Cystitis 0.69 1 0.4 0 Moderate Caffeine C0403632 Cystitis noninfective 0.69 1 0.4 0 Moderate Caffeine C0033575 Prostatic disorder 0.686 1 0.37 0 Moderate Caffeine C0424295 Hyperkinesia 0.677 1 0.463 0 Moderate Caffeine C0038363 Aphthous stomatitis 0.677 1 0.462 0 Moderate Caffeine C0033975 Psychotic disorder 0.677 1 0.4 0 Moderate Caffeine C0018834 Heartburn 0.67 1 0.437 0 Moderate Caffeine C0025323 Menorrhagia 0.666 1 0.32 0 Moderate Caffeine C2939147 Feeling hot 0.661 1 0.398 0 Moderate Caffeine C0836924 Thrombocytosis 0.66 1 0.463 0 Moderate Caffeine C1457883 Aggressive reaction 0.659 1 0.467 0 Moderate Caffeine C0235086 Muscle contractions involuntary 0.659 1 0.377 0 Moderate Caffeine C0438215 Laboratory test abnormal 0.658 1 0.435 0 Moderate Caffeine C0475858 Pruritus generalised 0.656 1 0.479 0 Moderate Caffeine C0235234 Dry throat 0.649 1 0.424 0 Moderate Caffeine C0011616 Dermatitis contact 0.645 1 0.493 0 Moderate Caffeine C0438142 Urine analysis abnormal 0.645 1 0.421 0 Moderate Caffeine C0235639 Urine abnormality 0.645 1 0.421 0 Moderate Caffeine C1142412 Vasodilation procedure 0.634 1 0.37 0 Moderate Caffeine C0042401 Vasodilation 0.634 1 0.37 0 Moderate Caffeine C0023518 Leukocytosis 0.633 1 0.321 0 Moderate Caffeine C0001824 Agranulocytosis 0.631 1 0.465 0 Moderate Caffeine C0595916 Nephropathy toxic 0.624 1 0.338 0 Moderate Caffeine C0025874 Metrorrhagia 0.607 1 0.454 0 Moderate Caffeine C2129214 Loose stools 0.604 1 0.472 0 Moderate Caffeine C0020039 Hostility 0.604 1 0.447 0 Moderate Caffeine C0036508 Seborrhoeic dermatitis 0.586 1 0.361 0 Moderate Caffeine C0034065 Pulmonary embolism 0.584 1 0.484 0 Moderate Caffeine C0037284 Skin lesion 0.584 1 0.398 0 Moderate Caffeine C0004245 Atrioventricular block 0.582 1 0.343 0 Moderate Caffeine C0034886 Proctalgia 0.58 1 0.424 0 Moderate Caffeine C0018418 Gynaecomastia 0.577 1 0.324 0 Moderate Caffeine C1167965 Urine output increased 0.577 1 0.273 0 Moderate Caffeine C0032617 Polyuria 0.577 1 0.273 0 Moderate Caffeine C0392156 Akathisia 0.569 1 0.418 0 Moderate Caffeine C0152517 Viral diarrhoea 0.562 1 0.353 0 Moderate Caffeine C0037317 Sleep disturbance 0.555 1 0.337 0 Moderate Caffeine C0022346 Jaundice 0.554 1 0.363 0 Moderate Caffeine C0392525 Nephrolithiasis 0.546 1 0.324 0 Moderate Caffeine C0233471 Flat affect 0.543 1 0.382 0 Moderate Caffeine C0085632 Apathy 0.543 1 0.382 0 Moderate Caffeine C0235996 Hepatic enzyme increased 0.54 1 0.243 0 Moderate Caffeine C0151836 Paranoid reaction 0.539 1 0.271 0 Moderate Caffeine C1456784 Paranoia 0.539 1 0.271 0 Moderate Caffeine C0086565 Hepatic function abnormal 0.532 1 0.496 0 Moderate Caffeine C0086543 Cataract 0.532 1 0.461 0 Moderate Caffeine C0040046 Thrombophlebitis 0.529 1 0.309 0 Moderate Caffeine C0152031 Joint swelling 0.5 0 0.612 1 Moderate Caffeine C0007222 Cardiovascular disorder 0.489 0 0.531 1 Moderate Caffeine C0014868 Oesophagitis 0.479 0 0.573 1 Moderate Caffeine C0853692 Blood triglycerides increased 0.464 0 0.546 1 Moderate Caffeine C0333355 Mucosal inflammation 0.453 0 0.536 1 Moderate Caffeine C0020557 Hypertriglyceridaemia 0.421 0 0.505 1 Moderate Caffeine C0311468 Blood bilirubin increased 0.42 0 0.582 1 Moderate Caffeine C0162119 Haemoglobin decreased 0.4 0 0.518 1 Moderate Caffeine C0392025 Enlargement abdomen 0.392 0 0.563 1 Moderate Caffeine C0020437 Hypercalcaemia 0.343 0 0.518 1 Moderate Caffeine C0001925 Albuminuria 0.314 0 0.529 1 Moderate Caffeine C0036454 Scotoma 0.519 0 0.37 0 Low Caffeine C0023067 Laryngitis 0.518 0 0.324 0 Low Caffeine C0022568 Keratitis 0.513 0 0.44 0 Low Caffeine C0022650 Calculus of kidney 0.509 0 0.313 0 Low Caffeine C2242737 Anorectal discomfort 0.505 0 0.465 0 Low Caffeine C1527344 Dysphonia 0.5 0 0.406 0 Low Caffeine C0030794 Pelvic pain 0.5 0 0.274 0 Low Caffeine C0020453 Hyperaesthesia 0.494 0 0.395 0 Low Caffeine C0020443 Hypercholesterolaemia 0.488 0 0.495 0 Low Caffeine C0042790 Disorder sight 0.487 0 0.324 0 Low Caffeine C1384666 Hearing impaired 0.484 0 0.384 0 Low Caffeine C0027051 Myocardial infarction 0.481 0 0.373 0 Low Caffeine C0948089 Acute coronary syndrome 0.481 0 0.373 0 Low Caffeine C0000833 Abscess 0.475 0 0.39 0 Low Caffeine C0151313 Peripheral sensory neuropathy 0.473 0 0.39 0 Low Caffeine C0007787 Transient ischaemic attack 0.471 0 0.436 0 Low Caffeine C0028084 Nightmare 0.471 0 0.405 0 Low Caffeine C0030920 Peptic ulcer 0.467 0 0.293 0 Low Caffeine C0011849 Diabetes mellitus 0.463 0 0.411 0 Low Caffeine C0549622 Sexual dysfunction 0.458 0 0.442 0 Low Caffeine C0001122 Acidosis 0.458 0 0.268 0 Low Caffeine C0149725 Lower respiratory tract infection 0.455 0 0.307 0 Low Caffeine C0235378 Hepatotoxicity 0.455 0 0.16 0 Low Caffeine C0151744 Myocardial ischaemia 0.454 0 0.418 0 Low Caffeine C0521591 Paraesthesia oral 0.454 0 0.296 0 Low Caffeine C0025517 Metabolic disorder 0.453 0 0.366 0 Low Caffeine C0917799 Hypersomnia 0.448 0 0.24 0 Low Caffeine C0020488 Hypernatraemia 0.448 0 0.235 0 Low Caffeine C0242422 Parkinsonism 0.447 0 0.339 0 Low Caffeine C0155169 Ocular hyperaemia 0.446 0 0.235 0 Low Caffeine C0151907 Skin discolouration 0.445 0 0.401 0 Low Caffeine C0034642 Rales 0.444 0 0.291 0 Low Caffeine C0423602 Sensation of foreign body 0.442 0 0.274 0 Low Caffeine C0017565 Gingival bleeding 0.441 0 0.191 0 Low Caffeine C0023533 Leukorrhea 0.439 0 0.434 0 Low Caffeine C0042514 Ventricular tachycardia 0.438 0 0.369 0 Low Caffeine C0025222 Melaena 0.436 0 0.387 0 Low Caffeine C1291077 Abdominal bloating 0.434 0 0.469 0 Low Caffeine C0024115 Lung disorder 0.425 0 0.406 0 Low Caffeine C0021290 Neonatal disorder 0.422 0 0.361 0 Low Caffeine C0236101 Neonatal and infancy disorder 0.422 0 0.361 0 Low Caffeine C0151740 Intracranial pressure increased 0.42 0 0.278 0 Low Caffeine C0234376 Action tremor 0.418 0 0.398 0 Low Caffeine C0017979 Glycosuria 0.418 0 0.264 0 Low Caffeine C0019360 Herpes zoster 0.417 0 0.303 0 Low Caffeine C0549356 Inflicted injury 0.416 0 0.356 0 Low Caffeine C0599918 Nephrotoxicity 0.416 0 0.329 0 Low Caffeine C0022281 Eye pruritus 0.415 0 0.369 0 Low Caffeine C0040053 Thrombosis 0.411 0 0.381 0 Low Caffeine C0085641 Rash pustular 0.409 0 0.494 0 Low Caffeine C0002957 Anger 0.408 0 0.336 0 Low Caffeine C0004610 Bacteraemia 0.407 0 0.335 0 Low Caffeine C0151315 Neck stiffness 0.403 0 0.281 0 Low Caffeine C1320474 Nuchal rigidity 0.403 0 0.281 0 Low Caffeine C0028734 Nocturia 0.402 0 0.273 0 Low Caffeine C0438717 Transaminases increased 0.402 0 0.271 0 Low Caffeine C0026837 Muscle rigidity 0.401 0 0.325 0 Low Caffeine C0038663 Suicide attempt 0.398 0 0.37 0 Low Caffeine C0237849 Skin exfoliation 0.397 0 0.449 0 Low Caffeine C0232459 Digestion impaired 0.396 0 0.307 0 Low Caffeine C0011253 Delusion 0.392 0 0.474 0 Low Caffeine C0020555 Hypertrichosis 0.392 0 0.223 0 Low Caffeine C0003578 Apnoea 0.39 0 0.492 0 Low Caffeine C0522055 Electrocardiogram abnormal 0.389 0 0.44 0 Low Caffeine C0332575 Redness 0.385 0 0.225 0 Low Caffeine C0151878 Electrocardiogram QT prolonged 0.38 0 0.218 0 Low Caffeine C0022904 Lacrimal disorder 0.376 0 0.301 0 Low Caffeine C0014724 Eructation 0.376 0 0.299 0 Low Caffeine C0034063 Pulmonary oedema 0.375 0 0.473 0 Low Caffeine C2364111 Ageusia 0.375 0 0.212 0 Low Caffeine C0151636 Ventricular extrasystoles 0.373 0 0.292 0 Low Caffeine C1609512 Vulvovaginal mycotic infection 0.366 0 0.265 0 Low Caffeine Asthenic conditions 0.364 0 0.254 0 Low Caffeine C0018790 Cardiac arrest 0.362 0 0.398 0 Low Caffeine C0027932 Neurosis 0.362 0 0.312 0 Low Caffeine C0017566 Gingival hyperplasia 0.362 0 0.198 0 Low Caffeine C0037195 Sinus headache 0.361 0 0.32 0 Low Caffeine C0231807 Dyspnoea exertional 0.358 0 0.343 0 Low Caffeine Taste disorders 0.358 0 0.26 0 Low Caffeine C0017672 Glossodynia 0.357 0 0.367 0 Low Caffeine C0234987 Dizziness postural 0.356 0 0.346 0 Low Caffeine C0027796 Neuralgia 0.355 0 0.277 0 Low Caffeine C0005741 Blepharitis 0.354 0 0.24 0 Low Caffeine C0085606 Micturition urgency 0.353 0 0.332 0 Low Caffeine C0022660 Renal failure acute 0.351 0 0.208 0 Low Caffeine C0877661 Application site burn 0.345 0 0.226 0 Low Caffeine C0853700 Application site erythema 0.344 0 0.218 0 Low Caffeine C0423153 Lacrimation 0.343 0 0.314 0 Low Caffeine C1527311 Brain oedema 0.342 0 0.222 0 Low Caffeine C0018099 Gout 0.341 0 0.475 0 Low Caffeine C0151479 Amylase increased 0.34 0 0.38 0 Low Caffeine C0020452 Hyperaemia 0.337 0 0.216 0 Low Caffeine C0003537 Aphasia 0.336 0 0.223 0 Low Caffeine C0019348 Herpes simplex 0.333 0 0.495 0 Low Caffeine C0011551 Depersonalisation 0.333 0 0.303 0 Low Caffeine C0233514 Abnormal behaviour 0.332 0 0.247 0 Low Caffeine C0162834 Skin hyperpigmentation 0.331 0 0.443 0 Low Caffeine C0518988 Tooth abscess 0.331 0 0.348 0 Low Caffeine C2937350 Abnormal ejaculation 0.33 0 0.232 0 Low Caffeine C0235969 Ejaculation disorder 0.33 0 0.232 0 Low Caffeine C0151746 Kidney function abnormal 0.328 0 0.36 0 Low Caffeine C0030846 Penis disorder 0.322 0 0.269 0 Low Caffeine C1720775 Renal tubular necrosis 0.321 0 0.149 0 Low Caffeine C0235266 Eye irritation 0.32 0 0.259 0 Low Caffeine C0027066 Myoclonus 0.319 0 0.413 0 Low Caffeine C0033687 Proteinuria 0.319 0 0.371 0 Low Caffeine C0338831 Mania 0.315 0 0.343 0 Low Caffeine C0948586 Protein urine present 0.313 0 0.365 0 Low Caffeine C0221201 Rash macular 0.312 0 0.305 0 Low Caffeine C0021053 Immune system disorder 0.311 0 0.343 0 Low Caffeine C0853193 Bipolar I disorder 0.31 0 0.231 0 Low Caffeine C2979982 Vaginal haemorrhage 0.309 0 0.474 0 Low Caffeine C0234518 Slurred speech 0.309 0 0.335 0 Low Caffeine C0239340 Edema of lower extremities 0.308 0 0.211 0 Low Caffeine C1761613 Conjunctival hyperaemia 0.305 0 0.308 0 Low Caffeine C0019521 Hiccups 0.304 0 0.233 0 Low Caffeine C0151603 Generalised oedema 0.301 0 0.478 0 Low Caffeine C0033771 Prurigo 0.298 0 0.308 0 Low Caffeine C0546817 Fluid overload 0.296 0 0.476 0 Low Caffeine C0497247 Blood pressure increased 0.296 0 0.295 0 Low Caffeine C1096035 Infusion site pain 0.296 0 0.224 0 Low Caffeine C0028961 Oliguria 0.296 0 0.197 0 Low Caffeine C0340464 Extrasystoles 0.293 0 0.275 0 Low Caffeine C0700345 Vulvovaginal candidiasis 0.291 0 0.2 0 Low Caffeine C0151883 Vesiculobullous rash 0.29 0 0.43 0 Low Caffeine C1322281 Rhinitis seasonal 0.29 0 0.245 0 Low Caffeine C0018621 Seasonal allergy 0.29 0 0.245 0 Low Caffeine C0011630 Fungal skin infection 0.286 0 0.247 0 Low Caffeine C0042035 Micturition disorder 0.285 0 0.32 0 Low Caffeine C0036104 Salivation 0.283 0 0.179 0 Low Caffeine C0011606 Dermatitis exfoliative 0.279 0 0.308 0 Low Caffeine C0700225 Serum creatinine increased 0.277 0 0.276 0 Low Caffeine C0234930 Skin odour abnormal 0.276 0 0.394 0 Low Caffeine C0221776 Oral pain 0.276 0 0.265 0 Low Caffeine C0233715 Speech impairment NOS 0.275 0 0.248 0 Low Caffeine C0011615 Dermatitis atopic 0.275 0 0.227 0 Low Caffeine C0085612 Ventricular arrhythmia 0.27 0 0.245 0 Low Caffeine C0014549 Grand mal convulsion 0.27 0 0.158 0 Low Caffeine C0019079 Haemoptysis 0.269 0 0.245 0 Low Caffeine C0015393 Congenital eye disorder 0.268 0 0.224 0 Low Caffeine C0085636 Photophobia 0.266 0 0.308 0 Low Caffeine C0234193 Sensation of heat 0.264 0 0.208 0 Low Caffeine C0476273 Respiratory distress 0.263 0 0.263 0 Low Caffeine C0235901 Lacrimation abnormal NOS 0.263 0 0.26 0 Low Caffeine C0700200 Presyncope 0.262 0 0.252 0 Low Caffeine C0149871 Deep vein thrombosis 0.261 0 0.366 0 Low Caffeine C0006852 Vaginal moniliasis 0.258 0 0.191 0 Low Caffeine C0151754 Lactic dehydrogenase activity increased 0.257 0 0.227 0 Low Caffeine C0870082 Hyperkeratosis 0.256 0 0.322 0 Low Caffeine C0013132 Drooling 0.256 0 0.175 0 Low Caffeine C0853714 Application site pruritus 0.255 0 0.209 0 Low Caffeine C0031256 Petechiae 0.254 0 0.328 0 Low Caffeine C1510410 Parosmia 0.253 0 0.308 0 Low Caffeine C0699744 Ear infection 0.252 0 0.331 0 Low Caffeine C2004489 Regurgitation 0.252 0 0.182 0 Low Caffeine Dyspeptic signs and symptoms 0.252 0 0.179 0 Low Caffeine C0235876 Depression aggravated 0.251 0 0.264 0 Low Caffeine C0151692 Impaired healing 0.25 0 0.19 0 Low Caffeine C0344315 Depressed mood 0.248 0 0.28 0 Low Caffeine C0006384 Bundle branch block 0.246 0 0.341 0 Low Caffeine C0853149 Blood lactate dehydrogenase increased 0.246 0 0.332 0 Low Caffeine C0015256 Excoriation 0.243 0 0.391 0 Low Caffeine C0004690 Balanitis 0.243 0 0.307 0 Low Caffeine C0239981 Hypoalbuminaemia 0.237 0 0.307 0 Low Caffeine C0151821 Accidental overdose 0.236 0 0.29 0 Low Caffeine C0085623 Akinesia 0.236 0 0.268 0 Low Caffeine C0043250 Wound 0.236 0 0.134 0 Low Caffeine C0854467 Myelosuppression 0.235 0 0.219 0 Low Caffeine C0019572 Hirsutism 0.234 0 0.141 0 Low Caffeine C0037383 Sneezing 0.234 0 0.14 0 Low Caffeine C0006145 Breast disorder 0.233 0 0.278 0 Low Caffeine C2937358 Cerebral haemorrhage 0.232 0 0.287 0 Low Caffeine C0549209 Feeling jittery 0.232 0 0.278 0 Low Caffeine C0043387 Yawning 0.229 0 0.259 0 Low Caffeine C0236826 Expressive language disorder 0.229 0 0.153 0 Low Caffeine C0424000 Suicidal ideation 0.228 0 0.227 0 Low Caffeine C0041582 Ulcer 0.226 0 0.297 0 Low Caffeine C0012739 Disseminated intravascular coagulation 0.225 0 0.2 0 Low Caffeine C0035508 Rhonchi 0.224 0 0.326 0 Low Caffeine C0032326 Pneumothorax 0.224 0 0.307 0 Low Caffeine C0973461 Dysphasia 0.224 0 0.154 0 Low Caffeine C0232726 Rectal tenesmus 0.222 0 0.342 0 Low Caffeine C0020550 Hyperthyroidism 0.222 0 0.226 0 Low Caffeine C0948595 Ocular discomfort 0.222 0 0.151 0 Low Caffeine C0234133 Extrapyramidal symptoms 0.221 0 0.257 0 Low Caffeine C0877303 Post procedural pain 0.221 0 0.133 0 Low Caffeine C0236071 Throat tightness 0.22 0 0.276 0 Low Caffeine C0278134 Sensory loss 0.22 0 0.262 0 Low Caffeine C0001623 Adrenal insufficiency 0.219 0 0.24 0 Low Caffeine C0232493 Epigastric pain 0.219 0 0.228 0 Low Caffeine C0427108 Unsteadiness 0.219 0 0.217 0 Low Caffeine C0032461 Polycythaemia 0.216 0 0.26 0 Low Caffeine C0033860 Psoriasis 0.215 0 0.285 0 Low Caffeine C0948349 Respiratory tract congestion 0.214 0 0.279 0 Low Caffeine C0040409 Tongue disorder 0.214 0 0.204 0 Low Caffeine C0018926 Haematemesis 0.214 0 0.187 0 Low Caffeine C0014236 Endophthalmitis 0.213 0 0.15 0 Low Caffeine C0521491 Application site pain 0.211 0 0.3 0 Low Caffeine C0235660 Galactorrhoea 0.211 0 0.215 0 Low Caffeine C0017675 Glossitis 0.211 0 0.132 0 Low Caffeine C0011206 Delirium 0.21 0 0.291 0 Low Caffeine C0038358 Gastric ulcer 0.21 0 0.264 0 Low Caffeine C0027651 Neoplasm 0.209 0 0.446 0 Low Caffeine C0920289 Sluggishness 0.209 0 0.204 0 Low Caffeine C0036341 Schizophrenia 0.209 0 0.204 0 Low Caffeine C0151477 Hormone level abnormal 0.209 0 0.204 0 Low Caffeine C0151752 Lactation female 0.209 0 0.204 0 Low Caffeine C0035258 Restless legs syndrome 0.209 0 0.204 0 Low Caffeine C0235280 Ototoxicity 0.208 0 0.222 0 Low Caffeine C0206062 Interstitial lung disease 0.208 0 0.162 0 Low Caffeine C0017601 Glaucoma 0.206 0 0.265 0 Low Caffeine C0151772 Manic psychosis 0.206 0 0.181 0 Low Caffeine C0002792 Anaphylactic shock 0.206 0 0.152 0 Low Caffeine C0020639 Hypoproteinaemia 0.204 0 0.302 0 Low Caffeine C0000729 Abdominal cramps 0.204 0 0.244 0 Low Caffeine C0919874 Post procedural haemorrhage 0.204 0 0.221 0 Low Caffeine C3203358 Hypoventilation 0.203 0 0.197 0 Low Caffeine C0005940 Bone disorder 0.202 0 0.35 0 Low Caffeine C0235886 Leg edema 0.202 0 0.273 0 Low Caffeine C0042510 Ventricular fibrillation 0.202 0 0.188 0 Low Caffeine C0234975 Convulsions aggravated 0.202 0 0.149 0 Low Caffeine C0877232 Peripheral swelling 0.201 0 0.275 0 Low Caffeine C0152025 Polyneuropathy 0.199 0 0.226 0 Low Caffeine C0151601 Conjunctival oedema 0.198 0 0.16 0 Low Caffeine C0085610 Sinus bradycardia 0.198 0 0.156 0 Low Caffeine C0392699 Dysaesthesia 0.195 0 0.37 0 Low Caffeine C0854382 Libido disorder 0.195 0 0.313 0 Low Caffeine C0156404 Menstruation irregular 0.195 0 0.246 0 Low Caffeine C0855775 Pulmonary function test decreased 0.194 0 0.223 0 Low Caffeine C0235063 Respiratory depression 0.194 0 0.223 0 Low Caffeine C0004144 Atelectasis 0.194 0 0.172 0 Low Caffeine C0016658 Fracture 0.194 0 0.162 0 Low Caffeine C0016655 Multiple fractures 0.194 0 0.162 0 Low Caffeine C0085595 Body odor 0.194 0 0.146 0 Low Caffeine C0521495 Application site rash 0.193 0 0.224 0 Low Caffeine C0019825 Hoarseness 0.193 0 0.217 0 Low Caffeine C0877046 Tooth infection 0.192 0 0.21 0 Low Caffeine C0020542 Pulmonary hypertension 0.191 0 0.288 0 Low Caffeine C0151632 Red blood cell sedimentation rate increased 0.191 0 0.267 0 Low Caffeine C0013922 Embolism 0.191 0 0.239 0 Low Caffeine C0027813 Neuritis 0.191 0 0.226 0 Low Caffeine C0004623 Bacterial infection 0.188 0 0.322 0 Low Caffeine C1112214 Vulvovaginal pruritus 0.188 0 0.172 0 Low Caffeine C0553723 Squamous cell carcinoma of skin 0.187 0 0.259 0 Low Caffeine C0026827 Hypotonia 0.187 0 0.215 0 Low Caffeine C1142135 Muscle relaxant therapy 0.187 0 0.215 0 Low Caffeine C0235032 Neurotoxicity 0.186 0 0.337 0 Low Caffeine C0006142 Breast cancer 0.186 0 0.311 0 Low Caffeine C0150450 Altered state of consciousness 0.185 0 0.325 0 Low Caffeine C0234238 Ache 0.185 0 0.261 0 Low Caffeine C0877336 Blood bilirubin decreased 0.185 0 0.135 0 Low Caffeine C0332534 Induration 0.183 0 0.255 0 Low Caffeine C0033777 Pruritus genital 0.182 0 0.295 0 Low Caffeine C0427008 Stiffness 0.182 0 0.188 0 Low Caffeine Red blood cell disorders 0.182 0 0.175 0 Low Caffeine C1737224 Post procedural swelling 0.182 0 0.163 0 Low Caffeine C0021167 Incontinence 0.181 0 0.249 0 Low Caffeine C2225524 Breast enlargement 0.181 0 0.171 0 Low Caffeine C0162298 Joint stiffness 0.181 0 0.138 0 Low Caffeine C0007971 Cheilitis 0.179 0 0.359 0 Low Caffeine C0020473 Hyperlipidaemia 0.179 0 0.315 0 Low Caffeine C0014394 Enuresis 0.179 0 0.272 0 Low Caffeine C0855333 Electrocardiogram QT corrected interval prolonged 0.179 0 0.145 0 Low Caffeine C0476281 Non-cardiac chest pain 0.179 0 0.13 0 Low Caffeine Blood and lymphatic system disorders 0.178 0 0.318 0 Low Caffeine C0013182 Drug hypersensitivity 0.178 0 0.254 0 Low Caffeine C0233459 Emotional disorder 0.178 0 0.17 0 Low Caffeine C0548823 Distress gastrointestinal 0.178 0 0.169 0 Low Caffeine C0085624 Burning sensation 0.177 0 0.278 0 Low Caffeine C0031154 Peritonitis 0.176 0 0.289 0 Low Caffeine C0152965 Staphylococcal bacteraemia 0.176 0 0.245 0 Low Caffeine C0231919 Nasal dryness 0.175 0 0.187 0 Low Caffeine C0260662 Auditory disorder NOS 0.175 0 0.183 0 Low Caffeine C0574002 Foot edema 0.174 0 0.222 0 Low Caffeine C0152032 Urinary hesitation 0.173 0 0.157 0 Low Caffeine C0021368 Inflammation 0.172 0 0.383 0 Low Caffeine C0021177 Libido increased 0.17 0 0.24 0 Low Caffeine C0009319 Colitis 0.168 0 0.289 0 Low Caffeine C0234047 Ejaculation delayed 0.168 0 0.21 0 Low Caffeine C0037278 Skin infection 0.168 0 0.169 0 Low Caffeine C0521490 Application site irritation 0.165 0 0.231 0 Low Caffeine C0233571 Excitement 0.165 0 0.228 0 Low Caffeine C0853891 Tumour flare 0.165 0 0.208 0 Low Caffeine C0007117 Basal cell carcinoma 0.164 0 0.157 0 Low Caffeine C0877211 General physical health deterioration 0.163 0 0.233 0 Low Caffeine C0241934 Hypomania 0.162 0 0.271 0 Low Caffeine C0241057 Skin burning sensation 0.162 0 0.132 0 Low Caffeine C0021308 Infarction 0.161 0 0.243 0 Low Caffeine C0278106 Ejaculation failure 0.161 0 0.218 0 Low Caffeine C0042256 Vaginal itching 0.161 0 0.158 0 Low Caffeine C0016436 Folliculitis 0.159 0 0.25 0 Low Caffeine C0426576 Gastrointestinal symptom NOS 0.159 0 0.175 0 Low Caffeine C0858259 Nasal discomfort 0.159 0 0.166 0 Low Caffeine C0016199 Flank pain 0.159 0 0.164 0 Low Caffeine C0877167 Psychomotor skills impaired 0.159 0 0.129 0 Low Caffeine C1696943 Hypoaesthesia facial 0.159 0 0.129 0 Low Caffeine C0009241 Cognitive disorder 0.159 0 0.129 0 Low Caffeine C0424230 Psychomotor retardation 0.159 0 0.129 0 Low Caffeine C0751265 Learning disability 0.159 0 0.129 0 Low Caffeine C0236024 Pharyngeal oedema 0.159 0 0.129 0 Low Caffeine C0024894 Mastitis 0.159 0 0.129 0 Low Caffeine C0027092 Myopia 0.159 0 0.129 0 Low Caffeine C0033038 Premature ejaculation 0.159 0 0.129 0 Low Caffeine C0554976 Bradyphrenia 0.159 0 0.129 0 Low Caffeine C0005758 Blister 0.158 0 0.21 0 Low Caffeine C0035229 Respiratory insufficiency 0.158 0 0.113 0 Low Caffeine C0235267 Eye redness 0.157 0 0.173 0 Low Caffeine C0085614 Atrioventricular block first degree 0.156 0 0.227 0 Low Caffeine C0221512 Stomach ache 0.156 0 0.18 0 Low Caffeine C0520589 Vulvovaginal dryness 0.155 0 0.309 0 Low Caffeine C0006826 Neoplasm malignant 0.154 0 0.321 0 Low Caffeine C0035854 Rosacea 0.154 0 0.132 0 Low Caffeine C1096250 Gastrointestinal discomfort 0.154 0 0.111 0 Low Caffeine C0151872 Prothrombin level increased 0.153 0 0.151 0 Low Caffeine C0152030 Skin irritation 0.152 0 0.235 0 Low Caffeine C0152198 Accommodation disorder 0.151 0 0.263 0 Low Caffeine C2939186 Mood alteration NOS 0.15 0 0.235 0 Low Caffeine C0240327 Taste metallic 0.15 0 0.177 0 Low Caffeine C0152027 Sensory disturbance 0.149 0 0.236 0 Low Caffeine C0010399 Crying 0.149 0 0.188 0 Low Caffeine C2242996 Tingling sensation 0.148 0 0.293 0 Low Caffeine C0014518 Toxic epidermal necrolysis 0.147 0 0.196 0 Low Caffeine C0236000 Pain in jaw 0.147 0 0.139 0 Low Caffeine C0015930 Foetal distress syndrome 0.147 0 0.068 0 Low Caffeine C0262397 Breast tenderness 0.146 0 0.111 0 Low Caffeine C0020578 Hyperventilation 0.146 0 0.105 0 Low Caffeine C0015376 Extravasation 0.144 0 0.251 0 Low Caffeine C0233565 Bradykinesia 0.144 0 0.236 0 Low Caffeine C0028643 Numbness 0.144 0 0.225 0 Low Caffeine C0948873 Flu symptoms 0.144 0 0.153 0 Low Caffeine C0522172 Feeling drunk 0.143 0 0.47 0 Low Caffeine C0026961 Mydriasis 0.143 0 0.132 0 Low Caffeine C3203661 Bilirubin total low 0.142 0 0.128 0 Low Caffeine C0151737 Intentional injury 0.142 0 0.128 0 Low Caffeine C3203646 Bilirubin total decreased 0.142 0 0.128 0 Low Caffeine C0036358 Schizophreniform disorder 0.142 0 0.128 0 Low Caffeine C0151898 Schizophrenic reaction 0.142 0 0.128 0 Low Caffeine C0003910 Phonological disorder 0.142 0 0.128 0 Low Caffeine C0854082 Blood prolactin increased 0.142 0 0.128 0 Low Caffeine C0553731 PRL increased 0.142 0 0.128 0 Low Caffeine C0036396 Sciatica 0.142 0 0.085 0 Low Caffeine C1971624 Appetite absent 0.141 0 0.276 0 Low Caffeine C0234632 Visual acuity reduced 0.141 0 0.218 0 Low Caffeine C0039503 Tendonitis 0.141 0 0.217 0 Low Caffeine C0151571 Corneal lesion 0.141 0 0.132 0 Low Caffeine C0231835 Tachypnoea 0.141 0 0.116 0 Low Caffeine C1510472 Drug dependence 0.14 0 0.175 0 Low Caffeine C1291078 Epigastric discomfort 0.14 0 0.175 0 Low Caffeine C0854113 Mucosal dryness 0.139 0 0.261 0 Low Caffeine C0002884 Hypochromic anaemia 0.139 0 0.245 0 Low Caffeine C0235025 Peripheral motor neuropathy 0.139 0 0.186 0 Low Caffeine C0030552 Paresis 0.139 0 0.174 0 Low Caffeine C0018932 Haematochezia 0.139 0 0.151 0 Low Caffeine C0239134 Productive cough 0.138 0 0.085 0 Low Caffeine C0019158 Hepatitis 0.137 0 0.128 0 Low Caffeine C1519353 Rash papular 0.136 0 0.264 0 Low Caffeine C0235437 Gravitational oedema 0.136 0 0.252 0 Low Caffeine C0853141 Therapeutic response unexpected 0.135 0 0.058 0 Low Caffeine C0541832 Chromaturia 0.134 0 0.079 0 Low Caffeine C0553732 Prothrombin level decreased 0.133 0 0.104 0 Low Caffeine C0030567 Parkinson's disease 0.132 0 0.161 0 Low Caffeine C0259799 Punctate keratitis 0.132 0 0.143 0 Low Caffeine C0030446 Ileus paralytic 0.132 0 0.11 0 Low Caffeine C0085616 Vasospasm 0.131 0 0.191 0 Low Caffeine C0039520 Tenosynovitis 0.131 0 0.153 0 Low Caffeine C0016512 Foot pain 0.13 0 0.227 0 Low Caffeine C0700502 Primary hypothyroidism 0.13 0 0.227 0 Low Caffeine C0521706 Cataract unilateral 0.13 0 0.227 0 Low Caffeine C0019917 Hordeolum 0.13 0 0.227 0 Low Caffeine C0392163 Corneal erosion 0.13 0 0.118 0 Low Caffeine C0520893 Localized exfoliation 0.129 0 0.148 0 Low Caffeine C0264893 Nodal arrhythmia 0.128 0 0.185 0 Low Caffeine C0018798 Heart malformation 0.128 0 0.18 0 Low Caffeine C0152021 Heart disease congenital 0.128 0 0.18 0 Low Caffeine C0021605 Insomnia NEC 0.128 0 0.18 0 Low Caffeine C0855329 Electrocardiogram change 0.128 0 0.18 0 Low Caffeine C0234894 Dermatitis acneiform 0.128 0 0.176 0 Low Caffeine C0036973 Shivering 0.128 0 0.166 0 Low Caffeine C0435002 Ligament sprain 0.128 0 0.145 0 Low Caffeine C0024305 Non-Hodgkin's lymphoma 0.128 0 0.091 0 Low Caffeine C0024299 Lymphoma 0.128 0 0.091 0 Low Caffeine C0520962 Pain localised 0.127 0 0.116 0 Low Caffeine C0853761 Blood potassium decreased 0.126 0 0.238 0 Low Caffeine C0877098 Application site dryness 0.126 0 0.152 0 Low Caffeine C0151763 Hepatocellular injury 0.126 0 0.112 0 Low Caffeine C0039239 Sinus tachycardia 0.125 0 0.264 0 Low Caffeine C0234369 Trembling 0.125 0 0.096 0 Low Caffeine C0085083 Ovarian hyperstimulation syndrome 0.125 0 0.093 0 Low Caffeine C0302295 Eruption 0.124 0 0.155 0 Low Caffeine C0406834 Wound secretion 0.123 0 0.083 0 Low Caffeine C0003962 Ascites 0.122 0 0.259 0 Low Caffeine C0242073 Pulmonary congestion 0.122 0 0.221 0 Low Caffeine C0549493 Alveolitis 0.122 0 0.201 0 Low Caffeine Urinary abnormalities 0.122 0 0.181 0 Low Caffeine C0036983 Septic shock 0.122 0 0.133 0 Low Caffeine C0008035 Chest wall pain 0.122 0 0.116 0 Low Caffeine C0085602 Polydipsia 0.121 0 0.199 0 Low Caffeine C0235490 Peripheral ischaemia 0.121 0 0.197 0 Low Caffeine C0009421 Coma 0.121 0 0.134 0 Low Caffeine C0043246 Laceration 0.121 0 0.103 0 Low Caffeine C1504411 Post procedural oedema 0.12 0 0.162 0 Low Caffeine C0042384 Vasculitis 0.12 0 0.101 0 Low Caffeine C0006444 Bursitis 0.118 0 0.185 0 Low Caffeine C0085583 Choreoathetosis 0.118 0 0.185 0 Low Caffeine C0948991 Injection site discolouration 0.118 0 0.173 0 Low Caffeine C0687707 Anorectal disorder 0.118 0 0.168 0 Low Caffeine C0392162 Sticky skin 0.118 0 0.157 0 Low Caffeine C0232431 Cold sweat 0.118 0 0.157 0 Low Caffeine C0011071 Sudden death 0.118 0 0.106 0 Low Caffeine C0016722 Frigidity 0.117 0 0.261 0 Low Caffeine C0015786 Female sexual arousal disorder 0.117 0 0.261 0 Low Caffeine C0424109 Tearfulness 0.117 0 0.175 0 Low Caffeine C0743400 Ejection fraction decreased 0.117 0 0.134 0 Low Caffeine C0033775 Anal pruritus 0.116 0 0.297 0 Low Caffeine C0239571 Foetor hepaticus 0.116 0 0.128 0 Low Caffeine C0023895 Liver disorder 0.116 0 0.128 0 Low Caffeine C0020672 Body temperature decreased 0.116 0 0.115 0 Low Caffeine C0413252 Hypothermia 0.116 0 0.115 0 Low Caffeine C0004095 Asthenopia 0.116 0 0.093 0 Low Caffeine C0235290 Taste bitter 0.116 0 0.093 0 Low Caffeine C0151838 Circumoral paresthesia 0.116 0 0.086 0 Low Caffeine C0241633 Vaginal dryness 0.115 0 0.215 0 Low Caffeine C2981158 Loss of libido 0.115 0 0.099 0 Low Caffeine C0008325 Cholecystitis 0.114 0 0.333 0 Low Caffeine C0018808 Cardiac murmur 0.114 0 0.122 0 Low Caffeine C0241136 Pain of skin 0.113 0 0.208 0 Low Caffeine C0236171 Infection susceptibility increased 0.113 0 0.089 0 Low Caffeine C0022672 Nephrosis lower nephron 0.113 0 0.089 0 Low Caffeine C0553576 Systemic mycosis 0.113 0 0.089 0 Low Caffeine C0235818 Bullous eruption 0.113 0 0.089 0 Low Caffeine C0241742 Wound haemorrhage 0.112 0 0.135 0 Low Caffeine C0015663 Fasting 0.112 0 0.086 0 Low Caffeine C0037320 Sleep terror 0.111 0 0.144 0 Low Caffeine C0855246 Abnormal sleep-related event 0.111 0 0.144 0 Low Caffeine C0271429 Otitis media acute 0.111 0 0.144 0 Low Caffeine C0014742 Erythema multiforme 0.111 0 0.12 0 Low Caffeine C0521508 Injection site bruising 0.111 0 0.109 0 Low Caffeine C0151698 Injection site haemorrhage 0.111 0 0.109 0 Low Caffeine C1302752 Abrasion NOS 0.11 0 0.395 0 Low Caffeine C0235857 Lacrimation decreased 0.11 0 0.27 0 Low Caffeine C0429097 QRS complex 0.11 0 0.27 0 Low Caffeine C0429098 Electrocardiogram QRS complex 0.11 0 0.27 0 Low Caffeine C0264886 Conduction disorder 0.11 0 0.27 0 Low Caffeine C0399459 Oral discomfort 0.11 0 0.105 0 Low Caffeine C0018520 Breath odour 0.109 0 0.253 0 Low Caffeine C0235318 Fullness abdominal 0.109 0 0.17 0 Low Caffeine C0037011 Shoulder pain 0.109 0 0.121 0 Low Caffeine C0242528 Azotaemia 0.109 0 0.085 0 Low Caffeine C0206061 Interstitial pneumonia 0.108 0 0.105 0 Low Caffeine C0038814 Sunburn 0.107 0 0.194 0 Low Caffeine C0919980 VIIth nerve paralysis 0.107 0 0.13 0 Low Caffeine C0038220 Status epilepticus 0.107 0 0.123 0 Low Caffeine C0032290 Pneumonia aspiration 0.107 0 0.107 0 Low Caffeine C0741494 Bilirubin total increased 0.107 0 0.107 0 Low Caffeine C0036690 Septicemia 0.107 0 0.078 0 Low Caffeine C0205204 Scab 0.106 0 0.229 0 Low Caffeine C0004626 Pneumonia bacterial 0.106 0 0.137 0 Low Caffeine C0240059 Intraventricular haemorrhage 0.106 0 0.137 0 Low Caffeine C1287298 Urine output 0.106 0 0.137 0 Low Caffeine C0152128 Drug withdrawal syndrome 0.106 0 0.136 0 Low Caffeine C0235467 Angina pectoris aggravated 0.106 0 0.117 0 Low Caffeine C1262144 Increased bronchial secretion 0.106 0 0.092 0 Low Caffeine C0235567 Sputum increased 0.106 0 0.092 0 Low Caffeine C0085680 Hypochloraemia 0.106 0 0.089 0 Low Caffeine C0008311 Cholangitis 0.105 0 0.234 0 Low Caffeine C0041364 Tumour lysis syndrome 0.105 0 0.223 0 Low Caffeine C0151970 Oesophageal ulcer 0.105 0 0.21 0 Low Caffeine C0333243 Pitting edema 0.105 0 0.197 0 Low Caffeine C0497365 Rash generalised 0.105 0 0.128 0 Low Caffeine C0030578 Paronychia 0.105 0 0.118 0 Low Caffeine C0549475 Lipase increased 0.104 0 0.267 0 Low Caffeine C0267792 Hepatobiliary disease 0.104 0 0.058 0 Low Caffeine C0852913 Blood amylase increased 0.103 0 0.202 0 Low Caffeine C0857353 Hypotensive 0.103 0 0.116 0 Low Caffeine C0013418 Abnormal labour 0.103 0 0.06 0 Low Caffeine C0347390 Skin papilloma 0.102 0 0.143 0 Low Caffeine C0541799 Bad taste 0.102 0 0.142 0 Low Caffeine C0919924 Pulmonary toxicity 0.102 0 0.118 0 Low Caffeine C0392386 Platelet count decreased 0.101 0 0.276 0 Low Caffeine C0026205 Miosis 0.101 0 0.199 0 Low Caffeine C0039240 Supraventricular tachycardia 0.101 0 0.191 0 Low Caffeine C0235896 Lung infiltration 0.101 0 0.126 0 Low Caffeine C0162281 Corneal deposits 0.1 0 0.123 0 Low Caffeine C0519030 Pneumonia klebsiella 0.1 0 0.123 0 Low Caffeine C0520459 Necrotizing enterocolitis 0.1 0 0.105 0 Low Caffeine C1442826 Necrotising enterocolitis neonatal 0.1 0 0.105 0 Low Caffeine C0948692 Necrotising colitis 0.1 0 0.105 0 Low Caffeine Infusion site reactions 0.099 0 0.181 0 Low Caffeine C1096403 Left ventricular ejection fraction decreased 0.099 0 0.114 0 Low Caffeine C0151599 Drug level increased 0.098 0 0.248 0 Low Caffeine C0151577 Creatinine renal clearance decreased 0.098 0 0.09 0 Low Caffeine C1096343 Infusion site reaction 0.098 0 0.085 0 Low Caffeine C0877517 Blood phosphorus decreased 0.097 0 0.21 0 Low Caffeine C0028173 NPN increased 0.097 0 0.11 0 Low Caffeine C0558401 Skin laceration 0.097 0 0.095 0 Low Caffeine C0030201 Postoperative pain 0.097 0 0.083 0 Low Caffeine C0007820 Cerebrovascular disorder 0.097 0 0.073 0 Low Caffeine C0235031 Neurological symptom 0.097 0 0.059 0 Low Caffeine C0011581 Depressive disorder 0.097 0 0.048 0 Low Caffeine C0013415 Dysthymic disorder 0.097 0 0.048 0 Low Caffeine C0010346 Crohn's disease 0.096 0 0.187 0 Low Caffeine C0085661 Onycholysis 0.096 0 0.177 0 Low Caffeine C0917798 Cerebral ischaemia 0.096 0 0.125 0 Low Caffeine C0434437 Joint sprain 0.096 0 0.125 0 Low Caffeine C0042998 Vulvovaginitis 0.096 0 0.107 0 Low Caffeine C0085096 Peripheral vascular disorder 0.096 0 0.088 0 Low Caffeine C0021775 Intermittent claudication 0.096 0 0.07 0 Low Caffeine C0041105 Trismus 0.095 0 0.156 0 Low Caffeine C0038354 Gastric disorder 0.095 0 0.149 0 Low Caffeine C0344320 Vivid dreams 0.095 0 0.149 0 Low Caffeine C0393593 Dystonia 0.095 0 0.123 0 Low Caffeine C0032131 Plasmacytoma 0.095 0 0.07 0 Low Caffeine C0269842 Uterine hypertonus 0.095 0 0.07 0 Low Caffeine C0269806 Failed induction of labour 0.095 0 0.07 0 Low Caffeine C0018811 Foetal heart rate 0.095 0 0.07 0 Low Caffeine C0026764 Plasma cell myeloma 0.095 0 0.07 0 Low Caffeine C0522153 Urine color abnormal 0.095 0 0.065 0 Low Caffeine C0009760 Conjunctival haemorrhage 0.094 0 0.164 0 Low Caffeine C0151205 Periorbital oedema 0.094 0 0.161 0 Low Caffeine C0259749 Autonomic neuropathy 0.094 0 0.141 0 Low Caffeine C0221706 Road traffic accident 0.094 0 0.102 0 Low Caffeine C0010481 Cushing's syndrome 0.094 0 0.086 0 Low Caffeine C0151998 Uterine spasm 0.094 0 0.083 0 Low Caffeine C0575805 Hand swelling 0.094 0 0.083 0 Low Caffeine C0233481 Worry 0.094 0 0.083 0 Low Caffeine C0678222 Carcinoma breast 0.094 0 0.083 0 Low Caffeine C0085692 Cystitis haemorrhagic 0.094 0 0.078 0 Low Caffeine C0521500 Injection site extravasation 0.093 0 0.189 0 Low Caffeine C0340909 Arteriovenous fistula thrombosis 0.093 0 0.189 0 Low Caffeine C0274312 Graft complication 0.093 0 0.189 0 Low Caffeine C0234708 Intraocular pressure increased 0.093 0 0.119 0 Low Caffeine C0221150 Odynophagia 0.093 0 0.117 0 Low Caffeine C0021831 Unspecified disorder of intestine 0.093 0 0.103 0 Low Caffeine C0020438 Hypercalciuria 0.093 0 0.1 0 Low Caffeine C0858833 Endometrial hypertrophy 0.093 0 0.076 0 Low Caffeine C0151734 Injection site inflammation 0.093 0 0.062 0 Low Caffeine C0877048 Oral fungal infection 0.092 0 0.262 0 Low Caffeine C0549385 Feeling of body temperature change 0.092 0 0.262 0 Low Caffeine C0018021 Goitre 0.092 0 0.262 0 Low Caffeine C0240897 Retinal exudates 0.092 0 0.262 0 Low Caffeine C0085584 Encephalopathy 0.092 0 0.242 0 Low Caffeine C0085642 Livedo reticularis 0.092 0 0.177 0 Low Caffeine C0018188 Granuloma 0.092 0 0.173 0 Low Caffeine C0017086 Gangrene 0.092 0 0.171 0 Low Caffeine C0151661 Peripheral gangrene 0.092 0 0.171 0 Low Caffeine C0151664 Gastrointestinal perforation 0.092 0 0.149 0 Low Caffeine C0876994 Cardiotoxicity 0.092 0 0.126 0 Low Caffeine C0424332 Breath holding attack 0.092 0 0.116 0 Low Caffeine C0235744 Breath holding 0.092 0 0.116 0 Low Caffeine C0853813 Local reaction 0.092 0 0.085 0 Low Caffeine C0039103 Synovitis 0.092 0 0.07 0 Low Caffeine C0032788 Postoperative hemorrhage 0.091 0 0.171 0 Low Caffeine C0332563 Papule 0.091 0 0.155 0 Low Caffeine C0034882 Rectal disorder 0.091 0 0.151 0 Low Caffeine C0426732 Prostatomegaly 0.091 0 0.128 0 Low Caffeine C1257843 Pseudomembranous colitis 0.091 0 0.101 0 Low Caffeine C0438237 Hepatic enzyme abnormal 0.091 0 0.088 0 Low Caffeine C0040425 Tonsillitis 0.091 0 0.071 0 Low Caffeine C0031039 Pericardial effusion 0.09 0 0.206 0 Low Caffeine C0234022 Anorgasmia 0.09 0 0.173 0 Low Caffeine C0423006 Eye discharge 0.09 0 0.111 0 Low Caffeine C0234655 Burning sensation in eye 0.09 0 0.111 0 Low Caffeine C0239454 Erythema of eyelid 0.09 0 0.111 0 Low Caffeine C0009766 Conjunctivitis allergic 0.09 0 0.111 0 Low Caffeine C0030318 Panic reaction 0.09 0 0.099 0 Low Caffeine C0877153 Neutropenic sepsis 0.09 0 0.098 0 Low Caffeine C0542101 Nasal burning 0.09 0 0.075 0 Low Caffeine C3160947 CNS toxicity 0.09 0 0.072 0 Low Caffeine C0542008 Injection site haematoma 0.09 0 0.065 0 Low Caffeine C0024236 Lymphoedema 0.089 0 0.175 0 Low Caffeine C0005747 Blepharospasm 0.089 0 0.171 0 Low Caffeine C0034186 Pyelonephritis 0.089 0 0.147 0 Low Caffeine C0001339 Pancreatitis acute 0.089 0 0.115 0 Low Caffeine C0002965 Angina unstable 0.089 0 0.094 0 Low Caffeine C0151718 Hypocholesterolaemia 0.089 0 0.094 0 Low Caffeine C0546884 Hypovolaemia 0.089 0 0.094 0 Low Caffeine C0861111 Cardioactive drug level increased 0.089 0 0.094 0 Low Caffeine C0581164 Digoxin level increased 0.089 0 0.094 0 Low Caffeine C0020255 Hydrocephalus 0.089 0 0.091 0 Low Caffeine C0018991 Hemiplegia 0.089 0 0.091 0 Low Caffeine C0851302 Shock hypoglycaemic 0.089 0 0.077 0 Low Caffeine C0162283 Nephrogenic diabetes insipidus 0.089 0 0.077 0 Low Caffeine C1527401 Shock insulin 0.089 0 0.077 0 Low Caffeine C0877359 Raised liver function tests 0.088 0 0.122 0 Low Caffeine C0853750 Blood magnesium decreased 0.088 0 0.095 0 Low Caffeine C0021845 Intestinal perforation 0.088 0 0.091 0 Low Caffeine C0038587 Withdrawal syndrome 0.088 0 0.089 0 Low Caffeine C0220981 Metabolic acidosis 0.088 0 0.084 0 Low Caffeine C0542075 Local throat irritation 0.088 0 0.059 0 Low Caffeine C0221773 Hyperamylasaemia 0.088 0 0.059 0 Low Caffeine C0030305 Pancreatitis 0.087 0 0.413 0 Low Caffeine C0234146 Areflexia 0.087 0 0.405 0 Low Caffeine C0011609 Drug eruption 0.087 0 0.093 0 Low Caffeine C0005586 Bipolar disorder 0.087 0 0.086 0 Low Caffeine C0549376 Plasma osmolality decreased 0.087 0 0.086 0 Low Caffeine C0751494 Convulsive seizure 0.087 0 0.086 0 Low Caffeine C0043049 Water intoxication 0.087 0 0.086 0 Low Caffeine C0853755 Blood osmolarity decreased 0.087 0 0.086 0 Low Caffeine C0235270 Keratopathy 0.087 0 0.062 0 Low Caffeine C0029456 Osteoporosis 0.086 0 0.173 0 Low Caffeine C0700361 Emotional distress 0.086 0 0.15 0 Low Caffeine C0039446 Telangiectasia 0.086 0 0.115 0 Low Caffeine C0035344 Retinopathy of prematurity 0.086 0 0.115 0 Low Caffeine C0150077 Skin breakdown 0.086 0 0.115 0 Low Caffeine C0860866 Potassium low 0.086 0 0.109 0 Low Caffeine C0037672 Somnambulism 0.085 0 0.245 0 Low Caffeine C0521509 Injection site induration 0.085 0 0.161 0 Low Caffeine C0553713 Breast pain female 0.085 0 0.133 0 Low Caffeine C0162835 Leukoderma 0.085 0 0.124 0 Low Caffeine C0022575 Keratoconjunctivitis sicca 0.085 0 0.112 0 Low Caffeine C0017411 Genital disorder female 0.085 0 0.106 0 Low Caffeine C0007286 Carpal tunnel syndrome 0.085 0 0.085 0 Low Caffeine C0235351 Tongue ulceration 0.085 0 0.072 0 Low Caffeine C0259817 Xerosis 0.084 0 0.153 0 Low Caffeine C0009324 Colitis ulcerative 0.084 0 0.151 0 Low Caffeine C3495920 Lacrimal structural disorder 0.084 0 0.151 0 Low Caffeine C0033247 Proctocolitis 0.084 0 0.151 0 Low Caffeine C0423736 Micturition burning 0.084 0 0.151 0 Low Caffeine C0000727 Acute abdomen 0.084 0 0.122 0 Low Caffeine C0023066 Laryngospasm 0.084 0 0.118 0 Low Caffeine C0235295 Abdominal distress 0.084 0 0.098 0 Low Caffeine C0151885 Reaction aggravation 0.084 0 0.094 0 Low Caffeine C0559546 Adverse reaction 0.084 0 0.094 0 Low Caffeine C0151773 Bone marrow depression 0.084 0 0.093 0 Low Caffeine C0029877 Otitis 0.083 0 0.126 0 Low Caffeine C0262662 Ventricular bigeminy 0.083 0 0.119 0 Low Caffeine C0031924 Piloerection 0.083 0 0.116 0 Low Caffeine C0521592 Hypoaesthesia oral 0.083 0 0.094 0 Low Caffeine C0029163 Mouth haemorrhage 0.083 0 0.091 0 Low Caffeine C0040586 Tracheobronchitis 0.083 0 0.091 0 Low Caffeine C0549445 Anaemia NOS aggravated 0.083 0 0.072 0 Low Caffeine C0040479 Torsade de pointes 0.083 0 0.063 0 Low Caffeine C0002994 Angioedema 0.083 0 0.058 0 Low Caffeine C0241157 Pustule 0.082 0 0.159 0 Low Caffeine C1610049 Application site exfoliation 0.082 0 0.137 0 Low Caffeine C0240941 Itchy scalp 0.082 0 0.111 0 Low Caffeine C0403673 Retrograde ejaculation 0.082 0 0.111 0 Low Caffeine C0035317 Retinal haemorrhage 0.082 0 0.108 0 Low Caffeine C0029134 Optic neuritis 0.082 0 0.108 0 Low Caffeine C0474378 Hair colour changes 0.082 0 0.101 0 Low Caffeine C0016385 Cardiac flutter 0.082 0 0.101 0 Low Caffeine C0221244 Dandruff 0.081 0 0.197 0 Low Caffeine C0231471 Posture abnormal 0.081 0 0.197 0 Low Caffeine C0686347 Tardive dyskinesia 0.081 0 0.197 0 Low Caffeine C0004377 Automatism 0.081 0 0.197 0 Low Caffeine C0085615 Bundle branch block right 0.081 0 0.197 0 Low Caffeine C0393761 Middle insomnia 0.081 0 0.197 0 Low Caffeine C0085605 Hepatic failure 0.081 0 0.127 0 Low Caffeine C0855704 Vital dye staining cornea present 0.081 0 0.104 0 Low Caffeine C0423232 Corneal staining 0.081 0 0.104 0 Low Caffeine C0029927 Ovarian cyst 0.081 0 0.102 0 Low Caffeine C0006105 Brain abscess 0.081 0 0.086 0 Low Caffeine C0085622 Monoplegia 0.081 0 0.086 0 Low Caffeine C0025289 Meningitis 0.081 0 0.086 0 Low Caffeine C0015469 Facial paralysis 0.081 0 0.086 0 Low Caffeine C0006114 Edema cerebral 0.081 0 0.086 0 Low Caffeine C0854069 Tumour pain 0.081 0 0.085 0 Low Caffeine C0240291 Mg reduced 0.081 0 0.085 0 Low Caffeine C1608945 Exfoliative rash 0.081 0 0.085 0 Low Caffeine C0151714 Hypermagnesaemia 0.081 0 0.075 0 Low Caffeine C0241705 Strangury 0.081 0 0.072 0 Low Caffeine C0004239 Atrial flutter 0.081 0 0.069 0 Low Caffeine C0023787 Lipodystrophy 0.081 0 0.027 0 Low Caffeine C0877192 Lipodystrophy acquired 0.081 0 0.027 0 Low Caffeine C0920102 Phosphorus low 0.08 0 0.203 0 Low Caffeine C0011127 Decubitus ulcer 0.08 0 0.113 0 Low Caffeine C0857496 Thromboembolic event 0.08 0 0.102 0 Low Caffeine C0038325 Stevens-Johnson syndrome 0.08 0 0.093 0 Low Caffeine C0085639 Fall 0.08 0 0.067 0 Low Caffeine C0339916 Viral upper respiratory tract infection 0.08 0 0.057 0 Low Caffeine C0234909 Nail changes 0.079 0 0.164 0 Low Caffeine C0231856 Breath sounds abnormal 0.079 0 0.124 0 Low Caffeine C0234192 Feeling cold 0.079 0 0.106 0 Low Caffeine C0856120 Multiple sclerosis relapse 0.078 0 0.199 0 Low Caffeine C0231303 Distress 0.078 0 0.167 0 Low Caffeine C0948695 White blood cell count low 0.078 0 0.101 0 Low Caffeine C1535975 Pelvic discomfort 0.078 0 0.101 0 Low Caffeine C1963790 Vulvovaginal burning sensation 0.078 0 0.101 0 Low Caffeine C0549310 Vaginal mycosis 0.078 0 0.101 0 Low Caffeine C0750466 Yeast infection 0.078 0 0.101 0 Low Caffeine C0236083 Burning feeling vagina 0.078 0 0.101 0 Low Caffeine C0015402 Eye haemorrhage 0.078 0 0.087 0 Low Caffeine C0027343 Ingrowing nail 0.078 0 0.076 0 Low Caffeine C0018794 Block heart 0.078 0 0.075 0 Low Caffeine C0038160 Staphylococcal infection 0.078 0 0.066 0 Low Caffeine C0795692 Hyperlactacidaemia 0.078 0 0.063 0 Low Caffeine C0043349 Xerophthalmia 0.077 0 0.186 0 Low Caffeine C0699893 Skin carcinoma 0.077 0 0.155 0 Low Caffeine C0036980 Cardiogenic shock 0.077 0 0.091 0 Low Caffeine C0853986 Lymphocyte count decreased 0.077 0 0.06 0 Low Caffeine C0853225 International normalised ratio increased 0.076 0 0.227 0 Low Caffeine C0242301 Furuncle 0.076 0 0.179 0 Low Caffeine C0016867 Furunculosis 0.076 0 0.179 0 Low Caffeine C0031099 Periodontitis 0.076 0 0.1 0 Low Caffeine C0476327 Serum amylase increased 0.076 0 0.092 0 Low Caffeine C0086525 Lassitude 0.076 0 0.088 0 Low Caffeine C0426636 Defaecation urgency 0.076 0 0.072 0 Low Caffeine C0151623 Enterocolitis haemorrhagic 0.076 0 0.068 0 Low Caffeine C0473237 Frank hematuria 0.076 0 0.068 0 Low Caffeine C0041959 Ureteritis 0.076 0 0.068 0 Low Caffeine C0151565 Hemorrhagic colitis 0.076 0 0.068 0 Low Caffeine C0234533 Convulsions generalised 0.076 0 0.068 0 Low Caffeine C0014038 Encephalitis 0.076 0 0.068 0 Low Caffeine C0015970 Fever of unknown origin 0.076 0 0.068 0 Low Caffeine C0221170 Muscle stiffness 0.076 0 0.066 0 Low Caffeine C3248383 Logorrhoea 0.076 0 0.066 0 Low Caffeine C0392702 Abnormal involuntary movements 0.076 0 0.066 0 Low Caffeine C0859023 Talkativeness 0.076 0 0.066 0 Low Caffeine C0233754 Derealisation 0.076 0 0.066 0 Low Caffeine C0015726 Fear 0.076 0 0.066 0 Low Caffeine C0424296 Disinhibition 0.076 0 0.066 0 Low Caffeine C0426747 Anal haemorrhage 0.076 0 0.058 0 Low Caffeine C0549400 Apgar score low 0.076 0 0.058 0 Low Caffeine C0410919 Bradycardia foetal 0.076 0 0.058 0 Low Caffeine C0549389 Wound discharge increased 0.076 0 0.058 0 Low Caffeine C0235839 Fever neonatal 0.076 0 0.058 0 Low Caffeine C0032797 Postpartum haemorrhage 0.076 0 0.058 0 Low Caffeine C0854706 Neonatal infection 0.076 0 0.058 0 Low Caffeine C0221780 Rectal discharge 0.076 0 0.058 0 Low Caffeine C0549395 Blood urea decreased 0.076 0 0.058 0 Low Caffeine C0032787 Postoperative complications NOS 0.076 0 0.058 0 Low Caffeine C0006147 Breast feeding 0.076 0 0.058 0 Low Caffeine C0235735 Unexpected therapeutic effect 0.076 0 0.058 0 Low Caffeine C0237326 Dyschezia 0.076 0 0.058 0 Low Caffeine C1112613 Neonatal tachypnoea 0.076 0 0.058 0 Low Caffeine C0022353 Jaundice neonatal 0.076 0 0.058 0 Low Caffeine C0269596 Haemorrhage in pregnancy 0.076 0 0.058 0 Low Caffeine C1141930 Post procedural complication 0.076 0 0.058 0 Low Caffeine C0410918 Tachycardia foetal 0.076 0 0.058 0 Low Caffeine C0158986 Hypoglycaemia neonatal 0.076 0 0.058 0 Low Caffeine C0270274 Vomiting neonatal 0.076 0 0.058 0 Low Caffeine C0235863 Delayed delivery 0.076 0 0.058 0 Low Caffeine C1285373 Respiratory disorder neonatal 0.076 0 0.058 0 Low Caffeine C0013609 Localised oedema 0.075 0 0.175 0 Low Caffeine C0021843 Intestinal obstruction 0.075 0 0.13 0 Low Caffeine C0596240 Cancer pain 0.075 0 0.125 0 Low Caffeine C1145628 Unspecified disorder of autonomic nervous system 0.075 0 0.097 0 Low Caffeine C0033046 Premenstrual syndrome 0.075 0 0.074 0 Low Caffeine C0863093 Cold symptoms 0.075 0 0.072 0 Low Caffeine C0947999 Blood urine present 0.075 0 0.063 0 Low Caffeine C0863070 Catheter site related reaction 0.075 0 0.063 0 Low Caffeine C1096213 Cannula site reaction 0.075 0 0.063 0 Low Caffeine C0042134 Uterine haemorrhage 0.075 0 0.06 0 Low Caffeine C0009443 Common cold 0.075 0 0.053 0 Low Caffeine C0520901 Increased skin sensitivity 0.074 0 0.152 0 Low Caffeine C0029400 Osteitis 0.074 0 0.121 0 Low Caffeine C0019214 Hepatosplenomegaly 0.074 0 0.121 0 Low Caffeine C0231875 Wheezing expiratory 0.074 0 0.121 0 Low Caffeine C0860564 Retinoic acid syndrome 0.074 0 0.121 0 Low Caffeine C2364164 Fluid imbalance 0.074 0 0.121 0 Low Caffeine C0031046 Pericarditis 0.074 0 0.121 0 Low Caffeine C0023052 Laryngeal oedema 0.074 0 0.121 0 Low Caffeine C0549386 Sensation of warmth 0.074 0 0.119 0 Low Caffeine C1527358 Phototoxicity 0.074 0 0.087 0 Low Caffeine C0239517 Facial paresthesia 0.074 0 0.087 0 Low Caffeine C0853811 Croup infectious 0.074 0 0.086 0 Low Caffeine C0038379 Strabismus 0.074 0 0.086 0 Low Caffeine C0080194 Muscle strain 0.074 0 0.086 0 Low Caffeine C0221100 Hangover 0.074 0 0.086 0 Low Caffeine C0234543 Postictal state 0.074 0 0.086 0 Low Caffeine C1325847 Sensitisation 0.074 0 0.078 0 Low Caffeine C0033246 Proctitis 0.074 0 0.077 0 Low Caffeine C1321898 Blood in stool 0.074 0 0.072 0 Low Caffeine C0264906 Atrioventricular block second degree 0.074 0 0.07 0 Low Caffeine C0028259 Nodule 0.074 0 0.051 0 Low Caffeine C0038525 Subarachnoid haemorrhage 0.073 0 0.101 0 Low Caffeine C0085681 Hyperphosphataemia 0.073 0 0.097 0 Low Caffeine C1290864 Abdominal disorder 0.073 0 0.096 0 Low Caffeine C0042594 Vestibular disorder 0.073 0 0.096 0 Low Caffeine C0700613 Anxiety state 0.073 0 0.096 0 Low Caffeine C0087169 Withdrawal symptom 0.073 0 0.096 0 Low Caffeine C0003079 Pupils unequal 0.073 0 0.096 0 Low Caffeine C0038367 Ulcerative stomatitis 0.073 0 0.096 0 Low Caffeine C0033931 Psychosomatic disease 0.073 0 0.096 0 Low Caffeine C1609536 Allergic bronchospasm 0.073 0 0.091 0 Low Caffeine C0856882 Potassium increased 0.073 0 0.078 0 Low Caffeine C0749249 Wide complex tachycardia 0.073 0 0.065 0 Low Caffeine C0861148 Proarrhythmia 0.073 0 0.065 0 Low Caffeine C0264909 Defect conduction intraventricular 0.073 0 0.065 0 Low Caffeine C0855931 Cardioactive drug level above therapeutic 0.073 0 0.065 0 Low Caffeine C0151699 Haemorrhage intracranial 0.073 0 0.062 0 Low Caffeine C0235919 Nerve root lesion 0.073 0 0.06 0 Low Caffeine C3489393 Hiatus hernia 0.073 0 0.06 0 Low Caffeine C0700594 Radiculopathy 0.073 0 0.06 0 Low Caffeine C0409962 Localized osteoarthritis 0.073 0 0.06 0 Low Caffeine C0034359 Pyuria 0.072 0 0.175 0 Low Caffeine C0162285 Eyelid oedema 0.072 0 0.174 0 Low Caffeine C0281981 Skin mass 0.072 0 0.147 0 Low Caffeine C0037287 Skin nodule 0.072 0 0.147 0 Low Caffeine C0266813 Faecal occult blood positive 0.072 0 0.137 0 Low Caffeine C0948070 Rhinalgia 0.072 0 0.137 0 Low Caffeine C0237938 Gastrointestinal ulcer 0.072 0 0.137 0 Low Caffeine C0877047 Occult blood positive 0.072 0 0.137 0 Low Caffeine C0037293 Acrochordon 0.072 0 0.125 0 Low Caffeine C0030354 Papilloma 0.072 0 0.125 0 Low Caffeine C0006079 Bowen's disease 0.072 0 0.125 0 Low Caffeine C0022572 Keratoacanthoma 0.072 0 0.125 0 Low Caffeine C0240557 Nasal irritation 0.072 0 0.09 0 Low Caffeine C0851886 Pneumocystis carinii infection 0.072 0 0.083 0 Low Caffeine C0235522 Vein disorder 0.072 0 0.083 0 Low Caffeine C0276908 Pneumocystis jirovecii infection 0.072 0 0.083 0 Low Caffeine C0004659 Bacteriuria 0.072 0 0.083 0 Low Caffeine C0476414 Thyroid function test abnormal 0.072 0 0.079 0 Low Caffeine C0549293 Nasal soreness 0.072 0 0.072 0 Low Caffeine C0264267 Nasal ulcer 0.072 0 0.072 0 Low Caffeine C0852795 Blood insulin increased 0.071 0 0.213 0 Low Caffeine C0007114 Skin cancer 0.071 0 0.144 0 Low Caffeine C0017563 Gingival disorder 0.071 0 0.129 0 Low Caffeine C0013369 Dysentery 0.071 0 0.129 0 Low Caffeine C0577115 Soft stools 0.071 0 0.129 0 Low Caffeine C0221345 Nail discolouration 0.071 0 0.095 0 Low Caffeine C0520887 Electrocardiogram ST segment depression 0.071 0 0.069 0 Low Caffeine C0232197 Cardiac fibrillation 0.071 0 0.06 0 Low Caffeine C0232498 Abdominal tenderness 0.071 0 0.047 0 Low Caffeine C1696708 Prehypertension 0.07 0 0.123 0 Low Caffeine C0022602 Actinic keratosis 0.07 0 0.12 0 Low Caffeine C0022603 Seborrhoeic keratosis 0.07 0 0.12 0 Low Caffeine C2607914 Rhinitis allergic 0.07 0 0.105 0 Low Caffeine C0018939 Blood disorder 0.07 0 0.094 0 Low Caffeine C0546959 Atrial tachycardia 0.07 0 0.08 0 Low Caffeine C0035410 Rhabdomyolysis 0.07 0 0.08 0 Low Caffeine C0948268 Haemodynamic instability 0.07 0 0.08 0 Low Caffeine C0221158 Multifocal atrial tachycardia 0.07 0 0.08 0 Low Caffeine C0236141 Electrocardiogram abnormal specific 0.07 0 0.074 0 Low Caffeine C0151564 Cogwheel rigidity 0.07 0 0.073 0 Low Caffeine C0233763 Hallucination, visual 0.07 0 0.073 0 Low Caffeine C0016242 Vitreous floaters 0.07 0 0.069 0 Low Caffeine C0028840 Ocular hypertension 0.07 0 0.069 0 Low Caffeine C0035321 Retinal tear 0.07 0 0.069 0 Low Caffeine C0042907 Vitreous detachment 0.07 0 0.069 0 Low Caffeine C0152006 Vitreous opacities 0.07 0 0.069 0 Low Caffeine C0005745 Eyelid ptosis 0.07 0 0.069 0 Low Caffeine C1096278 Anterior chamber inflammation 0.07 0 0.069 0 Low Caffeine C1535948 Retinal aneurysm 0.07 0 0.069 0 Low Caffeine C0030848 Peyronie's disease 0.07 0 0.066 0 Low Caffeine C0039591 Testicular pain 0.07 0 0.066 0 Low Caffeine C0541941 Erection increased 0.07 0 0.066 0 Low Caffeine C0497481 Penile pain 0.07 0 0.066 0 Low Caffeine C0522061 Abdominal pain localised 0.07 0 0.066 0 Low Caffeine C0156308 Penile oedema 0.07 0 0.066 0 Low Caffeine C2242621 Erection prolonged 0.07 0 0.066 0 Low Caffeine C0235195 Sedation 0.07 0 0.064 0 Low Caffeine C0239376 Pain of lower extremities 0.07 0 0.064 0 Low Caffeine C0542127 Oversedation 0.07 0 0.064 0 Low Caffeine C1096717 Pain during injection 0.07 0 0.064 0 Low Caffeine C0235194 Tranquillisation excessive 0.07 0 0.064 0 Low Caffeine C0600260 Obstructive airways disorder 0.07 0 0.064 0 Low Caffeine C0001883 Airway obstruction NOS 0.07 0 0.064 0 Low Caffeine C0376358 Prostate cancer 0.07 0 0.061 0 Low Caffeine C0236022 Neoplasm malignant aggravated 0.07 0 0.061 0 Low Caffeine C0742906 C-reactive protein increased 0.07 0 0.061 0 Low Caffeine C0001349 Acute phase reaction 0.07 0 0.061 0 Low Caffeine C0948048 Malignant neoplasm progression 0.07 0 0.061 0 Low Caffeine C0740330 Genital infection fungal 0.07 0 0.057 0 Low Caffeine C0015403 Eye infection 0.07 0 0.052 0 Low Caffeine C0003621 Appetite disorder 0.07 0 0.05 0 Low Caffeine C1280433 Lipoatrophy 0.07 0 0.032 0 Low Caffeine C0042345 Varicose vein 0.069 0 0.175 0 Low Caffeine C0221423 Sickness 0.069 0 0.142 0 Low Caffeine C0029261 Orgasm abnormal 0.069 0 0.103 0 Low Caffeine C1735368 Acute dystonia 0.069 0 0.101 0 Low Caffeine C0035222 Acute respiratory distress syndrome 0.069 0 0.075 0 Low Caffeine C0857448 Serum urea increased 0.069 0 0.071 0 Low Caffeine C0240671 Activated partial thromboplastin time prolonged 0.069 0 0.071 0 Low Caffeine C0231365 Urination impaired 0.069 0 0.068 0 Low Caffeine C0154251 Lipid metabolism disorder 0.069 0 0.067 0 Low Caffeine C0151622 Endometrial disorder 0.069 0 0.048 0 Low Caffeine C0151701 Pulmonary haemorrhage 0.068 0 0.1 0 Low Caffeine C0151609 Scrotal oedema 0.068 0 0.1 0 Low Caffeine C0860803 Glucose increased 0.068 0 0.093 0 Low Caffeine C0235398 Diabetes mellitus exacerbated 0.068 0 0.085 0 Low Caffeine C0235340 Buccal inflammation 0.068 0 0.082 0 Low Caffeine C0239150 Creatinine low 0.068 0 0.082 0 Low Caffeine C0852810 Blood creatinine decreased 0.068 0 0.082 0 Low Caffeine C0876973 Lung infection 0.068 0 0.082 0 Low Caffeine C0014869 Reflux esophagitis 0.068 0 0.082 0 Low Caffeine C0151966 Duodenal ulcer haemorrhage 0.068 0 0.082 0 Low Caffeine C0018129 Transplant rejection 0.068 0 0.071 0 Low Caffeine C1535849 Application site induration 0.067 0 0.152 0 Low Caffeine C0392197 Warmth 0.067 0 0.097 0 Low Caffeine C0541819 Burning rectal 0.067 0 0.097 0 Low Caffeine C0541919 Dystonic reaction 0.067 0 0.097 0 Low Caffeine C1112442 Female sexual dysfunction 0.067 0 0.081 0 Low Caffeine C1112443 Male sexual dysfunction 0.067 0 0.081 0 Low Caffeine C0750197 Sustained ventricular tachycardia 0.067 0 0.078 0 Low Caffeine C0010072 Coronary artery thrombosis 0.067 0 0.062 0 Low Caffeine C3160769 Major bleed 0.067 0 0.062 0 Low Caffeine C0151705 Retroperitoneal haemorrhage 0.067 0 0.062 0 Low Caffeine C0151814 Coronary artery occlusion 0.067 0 0.062 0 Low Caffeine C0919591 Urogenital haemorrhage 0.067 0 0.062 0 Low Caffeine C0239182 Watery diarrhoea 0.067 0 0.056 0 Low Caffeine C0002940 Aneurysm 0.066 0 0.17 0 Low Caffeine C0162823 Dermatitis irritant contact 0.066 0 0.166 0 Low Caffeine C0863084 Skin discomfort 0.066 0 0.166 0 Low Caffeine C0595877 Blood glucose increased 0.066 0 0.147 0 Low Caffeine C0221232 Welts 0.066 0 0.12 0 Low Caffeine C0853946 Pain worsened 0.066 0 0.114 0 Low Caffeine C0020546 Hypertensive crisis 0.066 0 0.113 0 Low Caffeine C0020540 Malignant hypertension 0.066 0 0.113 0 Low Caffeine C0549448 Haemoglobin increased 0.066 0 0.113 0 Low Caffeine C0853087 Nail abnormality NOS 0.066 0 0.113 0 Low Caffeine C0016514 Foot and mouth disease 0.066 0 0.111 0 Low Caffeine C1167779 Neutropenic infection 0.066 0 0.092 0 Low Caffeine C0010823 Cytomegalovirus infection 0.066 0 0.087 0 Low Caffeine C1579838 Sore mouth 0.066 0 0.087 0 Low Caffeine C0019270 Hernia 0.066 0 0.078 0 Low Caffeine C1536146 Eyelash darkening 0.066 0 0.075 0 Low Caffeine C1536145 Eyelash hyperpigmentation 0.066 0 0.075 0 Low Caffeine C0854438 Blepharal pigmentation 0.066 0 0.075 0 Low Caffeine C1142111 Eyelash discolouration 0.066 0 0.075 0 Low Caffeine C0849918 Eyelids pruritus 0.066 0 0.075 0 Low Caffeine C0423847 Growth of eyelashes 0.066 0 0.075 0 Low Caffeine C0007760 Cerebellar syndrome 0.066 0 0.075 0 Low Caffeine C0043345 Xeroderma 0.066 0 0.073 0 Low Caffeine C0852879 Pulmonary alveolar haemorrhage 0.066 0 0.073 0 Low Caffeine C0034155 Thrombotic thrombocytopenic purpura 0.066 0 0.073 0 Low Caffeine C0302810 Uraemic syndrome 0.066 0 0.073 0 Low Caffeine C0853123 Blood luteinising hormone increased 0.066 0 0.073 0 Low Caffeine C0860987 Phosphate low 0.066 0 0.073 0 Low Caffeine C0038941 Postoperative wound infection 0.066 0 0.073 0 Low Caffeine C0546956 Onychoclasis 0.066 0 0.073 0 Low Caffeine C0267716 Incisional hernia 0.066 0 0.073 0 Low Caffeine C2609269 Fasting hyperglycaemia 0.066 0 0.073 0 Low Caffeine C0240322 Menstruation delayed 0.066 0 0.073 0 Low Caffeine C2717961 Thrombotic microangiopathy 0.066 0 0.073 0 Low Caffeine C0019196 Hepatitis C 0.066 0 0.073 0 Low Caffeine C0018780 High frequency deafness 0.066 0 0.069 0 Low Caffeine C0520837 Forced expiratory volume decreased 0.066 0 0.069 0 Low Caffeine C0151729 Immunoglobulins increased 0.066 0 0.069 0 Low Caffeine C0003564 Aphonia 0.066 0 0.069 0 Low Caffeine C0018800 Cardiomegaly 0.065 0 0.173 0 Low Caffeine C0919582 Sudden onset of sleep 0.065 0 0.173 0 Low Caffeine C0600104 Compulsions 0.065 0 0.173 0 Low Caffeine C0032533 Polymyalgia rheumatica 0.065 0 0.173 0 Low Caffeine C0032231 Pleurisy 0.065 0 0.173 0 Low Caffeine C0004691 Balanoposthitis 0.065 0 0.173 0 Low Caffeine C0853008 Parkinson's disease aggravated 0.065 0 0.173 0 Low Caffeine C0021122 Impulse-control disorder 0.065 0 0.173 0 Low Caffeine C0235889 Arthritis aggravated 0.065 0 0.173 0 Low Caffeine C0014534 Epididymitis 0.065 0 0.173 0 Low Caffeine C0026266 Mitral valve incompetence 0.065 0 0.173 0 Low Caffeine C0343863 Genital candidiasis 0.065 0 0.173 0 Low Caffeine C0232286 Precordial pain 0.065 0 0.173 0 Low Caffeine C0018772 Partial hearing loss 0.065 0 0.173 0 Low Caffeine C0497327 Dementia 0.065 0 0.173 0 Low Caffeine C0855247 Sleep attacks 0.065 0 0.173 0 Low Caffeine C0042847 Vitamin B12 deficiency 0.065 0 0.173 0 Low Caffeine C0240717 Perineal pain 0.065 0 0.173 0 Low Caffeine C0162529 Colitis ischaemic 0.065 0 0.088 0 Low Caffeine C0270612 Leukoencephalopathy 0.065 0 0.088 0 Low Caffeine C1306587 Encephalopathy acute 0.065 0 0.088 0 Low Caffeine C0263008 Skin fibrosis 0.065 0 0.088 0 Low Caffeine C0010418 Cryptosporidiosis infection 0.065 0 0.088 0 Low Caffeine C0024440 Cystoid macular oedema 0.065 0 0.088 0 Low Caffeine C0878544 Cardiomyopathy 0.065 0 0.088 0 Low Caffeine C1292769 B-cell type acute leukaemia 0.065 0 0.088 0 Low Caffeine C0151799 Skin necrosis 0.065 0 0.088 0 Low Caffeine C0018784 Deafness neurosensory 0.065 0 0.088 0 Low Caffeine C0085436 Meningitis cryptococcal 0.065 0 0.088 0 Low Caffeine C0267412 Thrombosis mesenteric vessel 0.065 0 0.088 0 Low Caffeine C0271321 Madarosis 0.065 0 0.088 0 Low Caffeine C0022354 Jaundice cholestatic 0.065 0 0.078 0 Low Caffeine C0034880 Hyperacusis 0.065 0 0.078 0 Low Caffeine C0085077 Acute febrile neutrophilic dermatosis 0.065 0 0.07 0 Low Caffeine C0334634 Mantle cell lymphoma 0.065 0 0.07 0 Low Caffeine C0014335 Enteritis 0.065 0 0.07 0 Low Caffeine C0019294 Inguinal hernia 0.065 0 0.069 0 Low Caffeine C0026769 Multiple sclerosis 0.065 0 0.069 0 Low Caffeine C0040259 Tinea pedis 0.065 0 0.069 0 Low Caffeine C1611174 Post-traumatic pain 0.065 0 0.069 0 Low Caffeine C0038045 Sprain 0.065 0 0.068 0 Low Caffeine C0277585 Drug intolerance 0.065 0 0.068 0 Low Caffeine C0151611 Electroencephalogram abnormal 0.065 0 0.068 0 Low Caffeine C0234162 Dysmetria 0.065 0 0.068 0 Low Caffeine C0520588 Vulvovaginal pain 0.065 0 0.066 0 Low Caffeine C0234925 Oily skin 0.065 0 0.066 0 Low Caffeine C0152008 Vulvovaginal disorder 0.065 0 0.066 0 Low Caffeine C0236082 Vaginal pain 0.065 0 0.066 0 Low Caffeine C2945558 Vulvovaginitis trichomonal 0.065 0 0.066 0 Low Caffeine C0040923 Trichomonal vaginitis 0.065 0 0.066 0 Low Caffeine C0562057 Burning in throat 0.065 0 0.062 0 Low Caffeine C0423798 Increased tendency to bruise 0.065 0 0.062 0 Low Caffeine C2697368 Gastrointestinal tract irritation 0.065 0 0.062 0 Low Caffeine C0423636 Cardiac pain 0.065 0 0.061 0 Low Caffeine C1096049 Infusion site swelling 0.065 0 0.059 0 Low Caffeine C1096460 Infusion site phlebitis 0.065 0 0.059 0 Low Caffeine C0877365 Infusion site erythema 0.065 0 0.059 0 Low Caffeine C0555120 White blood cells urine positive 0.064 0 0.15 0 Low Caffeine Application and instillation site reactions 0.064 0 0.15 0 Low Caffeine C0241012 Serum ferritin decreased 0.064 0 0.15 0 Low Caffeine C0852922 Crohns disease aggravated 0.064 0 0.135 0 Low Caffeine C0007384 Cataplexy 0.064 0 0.128 0 Low Caffeine C0456511 Sleep paralysis 0.064 0 0.128 0 Low Caffeine C0858667 Urinary protein increased 0.064 0 0.111 0 Low Caffeine C0263383 Keratosis pilaris 0.064 0 0.109 0 Low Caffeine C0014743 Erythema nodosum 0.064 0 0.109 0 Low Caffeine C0341012 Oral herpes 0.064 0 0.108 0 Low Caffeine C0221384 Follicular conjunctivitis 0.064 0 0.103 0 Low Caffeine C0860499 Conjunctival follicles 0.064 0 0.103 0 Low Caffeine C0343084 Capillary leak syndrome 0.064 0 0.099 0 Low Caffeine C0849916 Generalised erythema 0.064 0 0.099 0 Low Caffeine C0026766 Multi-organ failure 0.064 0 0.099 0 Low Caffeine C0948441 Venoocclusive disease 0.064 0 0.099 0 Low Caffeine C0242966 Systemic inflammatory response syndrome 0.064 0 0.099 0 Low Caffeine C0750426 White blood cell count increased 0.064 0 0.074 0 Low Caffeine C0948715 Infusion related reaction 0.064 0 0.074 0 Low Caffeine C1167675 Application site folliculitis 0.064 0 0.071 0 Low Caffeine C0860871 Sodium decreased 0.064 0 0.071 0 Low Caffeine C0029928 Ovarian disorder 0.064 0 0.068 0 Low Caffeine C0549383 Ovarian hyperstimulation 0.064 0 0.068 0 Low Caffeine C0235296 Epigastric pain not food-related 0.064 0 0.067 0 Low Caffeine C0581912 Sensation of heaviness 0.064 0 0.067 0 Low Caffeine C0235698 Abdominal distension gaseous 0.064 0 0.067 0 Low Caffeine C0231686 Unsteady gait 0.064 0 0.067 0 Low Caffeine C0235721 Heaviness in limbs 0.064 0 0.067 0 Low Caffeine C0751295 Memory loss 0.064 0 0.067 0 Low Caffeine C0235018 Localised numbness 0.064 0 0.067 0 Low Caffeine C0151579 Crystalluria 0.064 0 0.062 0 Low Caffeine C1167791 Skin toxicity 0.063 0 0.183 0 Low Caffeine C0877127 Application site papules 0.063 0 0.119 0 Low Caffeine C0010038 Corneal opacity 0.063 0 0.068 0 Low Caffeine C0080276 Urogenital disorder 0.063 0 0.058 0 Low Caffeine C0003813 Sinus arrhythmia 0.062 0 0.184 0 Low Caffeine C0040485 Torticollis 0.062 0 0.175 0 Low Caffeine C0877322 Muscle tightness 0.062 0 0.126 0 Low Caffeine C0026846 Muscle atrophy 0.062 0 0.097 0 Low Caffeine C0751466 Phonophobia 0.062 0 0.097 0 Low Caffeine C0235129 Feeling strange 0.062 0 0.097 0 Low Caffeine C0234222 Sensation of pressure 0.062 0 0.097 0 Low Caffeine C0392548 Cauda equina syndrome 0.062 0 0.083 0 Low Caffeine C0026857 Musculoskeletal disorder 0.062 0 0.083 0 Low Caffeine C0853777 Blood albumin decreased 0.062 0 0.082 0 Low Caffeine C0021141 Inappropriate antidiuretic hormone secretion 0.062 0 0.074 0 Low Caffeine C0860864 Albumin low 0.062 0 0.073 0 Low Caffeine C0233569 Physical wandering 0.062 0 0.073 0 Low Caffeine C0235939 Crying abnormal 0.062 0 0.073 0 Low Caffeine C0151602 Swelling face 0.062 0 0.059 0 Low Caffeine C0235496 Oral mucosal petechiae 0.062 0 0.059 0 Low Caffeine C0949103 Catheter site pain 0.062 0 0.059 0 Low Caffeine C0852995 Injection site pruritus 0.062 0 0.059 0 Low Caffeine C0860239 Catheter related infection 0.062 0 0.059 0 Low Caffeine C0852625 Injection site erythema 0.062 0 0.059 0 Low Caffeine C0521505 Injection site dermatitis 0.062 0 0.059 0 Low Caffeine C0521499 Injection site pigmentation changes 0.062 0 0.059 0 Low Caffeine C0085654 Injection site granuloma 0.062 0 0.059 0 Low Caffeine C0595902 Blood chloride decreased 0.062 0 0.059 0 Low Caffeine C0265031 Haemorrhoidal haemorrhage 0.062 0 0.059 0 Low Caffeine C0853737 Blood bicarbonate increased 0.062 0 0.059 0 Low Caffeine C0860901 Protein total decreased 0.062 0 0.059 0 Low Caffeine C0267028 Lip pain 0.062 0 0.059 0 Low Caffeine C0266998 Oral soft tissue disorder NOS 0.062 0 0.059 0 Low Caffeine C0238844 Respiratory sounds decreased 0.062 0 0.059 0 Low Caffeine C0267033 Lip ulceration 0.062 0 0.059 0 Low Caffeine C0235299 Right upper quadrant pain 0.062 0 0.059 0 Low Caffeine C0277799 Intermittent fever 0.062 0 0.059 0 Low Caffeine C0151605 Injection site swelling 0.062 0 0.059 0 Low Caffeine C0026636 Oral disorder 0.062 0 0.059 0 Low Caffeine C0019163 Hepatitis B 0.062 0 0.059 0 Low Caffeine C0274435 Transfusion reaction 0.062 0 0.059 0 Low Caffeine C0856136 Fatigue aggravated 0.062 0 0.059 0 Low Caffeine C0948815 Catheter site erythema 0.062 0 0.059 0 Low Caffeine C1619702 Device related infection 0.062 0 0.059 0 Low Caffeine C0852909 Blood bicarbonate decreased 0.062 0 0.059 0 Low Caffeine C0235966 Dreaming excessive 0.062 0 0.058 0 Low Caffeine C0042138 Uterine neoplasm 0.062 0 0.058 0 Low Caffeine C0235960 Parkinsonism aggravated 0.062 0 0.058 0 Low Caffeine C0917816 Mental deficiency 0.062 0 0.058 0 Low Caffeine C0042251 Vaginal disorder 0.062 0 0.055 0 Low Caffeine C0010695 Cystocele 0.062 0 0.055 0 Low Caffeine C0156369 Uterine polyp 0.062 0 0.055 0 Low Caffeine C2747891 Device capturing issue 0.062 0 0.053 0 Low Caffeine C1456822 Claudication 0.062 0 0.053 0 Low Caffeine C0037188 Sinoatrial block 0.062 0 0.053 0 Low Caffeine C0277925 Peripheral coldness 0.062 0 0.053 0 Low Caffeine C0221725 Bronchial obstruction 0.062 0 0.053 0 Low Caffeine C0857073 Cold hands & feet 0.062 0 0.053 0 Low Caffeine C0000772 Multiple congenital abnormalities 0.061 0 0.211 0 Low Caffeine C0006285 Bronchopneumonia 0.061 0 0.211 0 Low Caffeine C0159056 Abnormal chest sounds NOS 0.061 0 0.158 0 Low Caffeine C0851536 Administration site reaction 0.061 0 0.158 0 Low Caffeine C0016397 Localised infection 0.061 0 0.158 0 Low Caffeine C0006625 Cachexia 0.061 0 0.097 0 Low Caffeine C0023418 Leukaemia 0.061 0 0.097 0 Low Caffeine C0240972 Scrotal erythema 0.061 0 0.097 0 Low Caffeine C0035333 Retinitis 0.061 0 0.097 0 Low Caffeine C0494165 Metastases to liver 0.061 0 0.097 0 Low Caffeine C0856554 Hepatic cancer metastatic 0.061 0 0.097 0 Low Caffeine C2173677 Renal cyst 0.061 0 0.086 0 Low Caffeine C1274926 Stinging skin 0.061 0 0.074 0 Low Caffeine C0263492 Ingrown hair 0.061 0 0.074 0 Low Caffeine C0549150 Pseudofolliculitis barbae 0.061 0 0.074 0 Low Caffeine C0033581 Prostatitis 0.061 0 0.07 0 Low Caffeine C1268766 Change in blood pressure 0.061 0 0.07 0 Low Caffeine C0549405 Blood pressure fluctuation 0.061 0 0.07 0 Low Caffeine C0026603 Motion sickness 0.061 0 0.07 0 Low Caffeine C0086769 Panic attack 0.061 0 0.07 0 Low Caffeine C0393760 Initial insomnia 0.061 0 0.07 0 Low Caffeine C0595929 Cholesterol serum elevated 0.061 0 0.07 0 Low Caffeine C0151826 Retrosternal pain 0.061 0 0.07 0 Low Caffeine C0743680 Eye oedema 0.061 0 0.069 0 Low Caffeine C0857236 Rash both legs 0.061 0 0.069 0 Low Caffeine C1096001 Application site swelling 0.061 0 0.067 0 Low Caffeine C0234936 Application site oedema 0.061 0 0.067 0 Low Caffeine C0149514 Acute bronchitis 0.061 0 0.065 0 Low Caffeine C0239295 Oesophageal candidiasis 0.061 0 0.064 0 Low Caffeine C0235855 Sepsis secondary 0.061 0 0.064 0 Low Caffeine C0221714 Injection site infection 0.061 0 0.064 0 Low Caffeine C1535939 Pneumocystis jirovecii pneumonia 0.061 0 0.064 0 Low Caffeine C0035305 Retinal detachment 0.061 0 0.064 0 Low Caffeine C0740299 Blood culture positive 0.061 0 0.064 0 Low Caffeine C0242339 Dyslipidaemia 0.061 0 0.058 0 Low Caffeine C0854331 Herpes simplex dermatitis 0.061 0 0.057 0 Low Caffeine C1262170 Herpes dermatitis 0.061 0 0.057 0 Low Caffeine C0029560 Other conjunctivitis 0.061 0 0.057 0 Low Caffeine C0026393 Molluscum contagiosum 0.061 0 0.057 0 Low Caffeine C0008049 Varicella 0.061 0 0.057 0 Low Caffeine C0549336 Asthma aggravated 0.061 0 0.057 0 Low Caffeine C0021099 Impetigo 0.061 0 0.057 0 Low Caffeine C0036689 Pharyngitis streptococcal 0.061 0 0.057 0 Low Caffeine C0003615 Appendicitis 0.061 0 0.051 0 Low Caffeine C0085693 Acute appendicitis 0.061 0 0.051 0 Low Caffeine C0542184 Reaction gastrointestinal 0.061 0 0.051 0 Low Caffeine C0235074 Tongue paralysis 0.06 0 0.188 0 Low Caffeine C0236068 Swollen tongue 0.06 0 0.188 0 Low Caffeine C0438167 Electrocardiogram T wave abnormal 0.06 0 0.188 0 Low Caffeine C0520888 Electrocardiogram T wave inversion 0.06 0 0.188 0 Low Caffeine C0085637 Oculogyric crisis 0.06 0 0.188 0 Low Caffeine C0861021 Insulin C-peptide increased 0.06 0 0.188 0 Low Caffeine C0024282 Lymphocytosis 0.06 0 0.184 0 Low Caffeine C0151717 Skin hypertrophy 0.06 0 0.184 0 Low Caffeine C0438716 Chest pressure 0.06 0 0.108 0 Low Caffeine C0595930 Blood cholesterol increased 0.06 0 0.088 0 Low Caffeine C0026650 Movement disorder 0.06 0 0.088 0 Low Caffeine C1458155 Breast neoplasm 0.06 0 0.084 0 Low Caffeine C0151547 Cataract specified 0.06 0 0.084 0 Low Caffeine C0006325 Bruxism 0.06 0 0.08 0 Low Caffeine C0542165 Pseudoparkinsonism 0.06 0 0.08 0 Low Caffeine C0853326 Dyspnoea exacerbated 0.06 0 0.08 0 Low Caffeine C0151596 Tongue discolouration 0.06 0 0.08 0 Low Caffeine C0002063 Alkalosis 0.06 0 0.073 0 Low Caffeine C0001126 Renal tubular acidosis 0.06 0 0.073 0 Low Caffeine C0153251 Respiratory moniliasis 0.06 0 0.07 0 Low Caffeine C0042749 Viraemia 0.06 0 0.07 0 Low Caffeine C0343886 Gastrointestinal candidiasis 0.06 0 0.07 0 Low Caffeine C0877042 Graft loss 0.06 0 0.07 0 Low Caffeine C0221155 Systolic hypertension 0.06 0 0.069 0 Low Caffeine C0877097 Application site vesicles 0.06 0 0.069 0 Low Caffeine C0231837 Respiratory rate decreased 0.06 0 0.069 0 Low Caffeine C0235222 Diastolic hypertension 0.06 0 0.069 0 Low Caffeine C0392676 Hyperpyrexia 0.06 0 0.069 0 Low Caffeine C0877306 Iris hyperpigmentation 0.06 0 0.065 0 Low Caffeine C0017412 Genital disorder male 0.06 0 0.064 0 Low Caffeine C0178829 Reproductive tract disorder 0.06 0 0.064 0 Low Caffeine C0022081 Iritis 0.06 0 0.064 0 Low Caffeine C0038986 Sweat gland disorder 0.06 0 0.064 0 Low Caffeine C0042164 Uveitis 0.06 0 0.064 0 Low Caffeine C0028841 Hypotony of eye 0.06 0 0.064 0 Low Caffeine C0240515 Nipple pain 0.06 0 0.05 0 Low Caffeine C0857144 Metastatic pain 0.06 0 0.05 0 Low Caffeine C0240521 Nipple tenderness 0.06 0 0.05 0 Low Caffeine C0156312 Testicular atrophy 0.06 0 0.05 0 Low Caffeine C0234428 Consciousness abnormal 0.06 0 0.05 0 Low Caffeine C0032781 Postnasal drip 0.06 0 0.045 0 Low Caffeine C2938875 Upper-airway cough syndrome 0.06 0 0.045 0 Low Caffeine C0027540 Necrosis 0.06 0 0.044 0 Low Caffeine C1142524 Asymptomatic hyperlactatemia 0.06 0 0.044 0 Low Caffeine C0162628 Viral skin infection 0.059 0 0.135 0 Low Caffeine C0206160 Reticulocytosis 0.059 0 0.127 0 Low Caffeine C0029118 Opportunistic infection 0.059 0 0.125 0 Low Caffeine C2712122 Blood pressure normal 0.059 0 0.115 0 Low Caffeine C0857121 Hypertensive 0.059 0 0.115 0 Low Caffeine C0232292 Chest tightness 0.059 0 0.112 0 Low Caffeine C0232495 Abdominal pain lower 0.059 0 0.082 0 Low Caffeine C0021899 IUD expelled 0.059 0 0.082 0 Low Caffeine C0549478 Device expulsion 0.059 0 0.082 0 Low Caffeine C0032519 Polymenorrhoea 0.059 0 0.082 0 Low Caffeine C0232943 Menometrorrhagia 0.059 0 0.082 0 Low Caffeine C0020624 Hypomenorrhoea 0.059 0 0.082 0 Low Caffeine C0863113 Hypotension symptomatic 0.059 0 0.08 0 Low Caffeine C1704381 Glucose decreased 0.059 0 0.078 0 Low Caffeine C0037926 Spinal cord compression 0.059 0 0.077 0 Low Caffeine Mental impairment disorders 0.059 0 0.077 0 Low Caffeine C0558148 Yellow skin 0.059 0 0.077 0 Low Caffeine C0236061 Haptoglobin increased 0.059 0 0.077 0 Low Caffeine C1258215 Ileus 0.059 0 0.076 0 Low Caffeine C0024248 Lymphocele 0.059 0 0.066 0 Low Caffeine C0025202 Malignant melanoma 0.059 0 0.066 0 Low Caffeine C0151779 Melanoma skin 0.059 0 0.066 0 Low Caffeine C0029445 Osteonecrosis 0.059 0 0.066 0 Low Caffeine C0549463 X-linked lymphoproliferative syndrome 0.059 0 0.066 0 Low Caffeine C0029443 Osteomyelitis 0.059 0 0.066 0 Low Caffeine C0024314 Lymphoproliferative disorder 0.059 0 0.066 0 Low Caffeine C0007097 Carcinoma 0.059 0 0.066 0 Low Caffeine C0543467 Surgery 0.059 0 0.062 0 Low Caffeine C0549433 Surgical intervention 0.059 0 0.062 0 Low Caffeine C0026848 Myopathy 0.059 0 0.061 0 Low Caffeine C0018674 Head injury 0.059 0 0.06 0 Low Caffeine C0031345 Pharyngeal disorder 0.059 0 0.06 0 Low Caffeine C0743668 Limb injury 0.059 0 0.06 0 Low Caffeine C0151517 Atrioventricular block complete 0.059 0 0.057 0 Low Caffeine C0235750 Hypertension worsened 0.058 0 0.117 0 Low Caffeine C0595883 Blood glucose decreased 0.058 0 0.086 0 Low Caffeine C0028949 Oligomenorrhoea 0.058 0 0.086 0 Low Caffeine C1262299 Oral papilloma 0.058 0 0.083 0 Low Caffeine C0030489 Paraproteinaemia 0.058 0 0.083 0 Low Caffeine C0342579 Electrolyte imbalance 0.058 0 0.083 0 Low Caffeine C0151625 Enzyme abnormality 0.058 0 0.065 0 Low Caffeine C0949070 Upper respiratory tract congestion 0.058 0 0.064 0 Low Caffeine C0235050 Tingling skin 0.058 0 0.063 0 Low Caffeine C0152459 Skin striae 0.058 0 0.061 0 Low Caffeine C0333641 Atrophy 0.058 0 0.061 0 Low Caffeine C0392160 Application site atrophy 0.058 0 0.061 0 Low Caffeine C0264268 Nasal septum ulceration 0.058 0 0.061 0 Low Caffeine C0853254 Nasal passage irritation 0.058 0 0.061 0 Low Caffeine C0236072 Bronchospasm paradoxical 0.058 0 0.061 0 Low Caffeine C0520573 Buffalo hump 0.058 0 0.061 0 Low Caffeine C0235439 Ankle edema 0.058 0 0.061 0 Low Caffeine C0151514 Skin atrophy 0.058 0 0.061 0 Low Caffeine C1262113 Lipohypertrophy 0.058 0 0.061 0 Low Caffeine C0332601 Cushingoid 0.058 0 0.061 0 Low Caffeine C0033893 Tension headache 0.058 0 0.055 0 Low Caffeine Vascular hypertensive disorders 0.058 0 0.054 0 Low Caffeine C0009663 Anogenital warts 0.058 0 0.054 0 Low Caffeine C0004998 Benign neoplasm of skin 0.058 0 0.054 0 Low Caffeine Apocrine and eccrine gland disorders 0.058 0 0.054 0 Low Caffeine Joint related signs and symptoms 0.058 0 0.054 0 Low Caffeine Urinary tract signs and symptoms 0.058 0 0.054 0 Low Caffeine C0151936 Tendon disorder 0.058 0 0.048 0 Low Caffeine C0042131 Uterine disorder 0.058 0 0.048 0 Low Caffeine C0555724 Lip dry 0.058 0 0.042 0 Low Caffeine C1141938 Ocular icterus 0.058 0 0.042 0 Low Caffeine C0856151 Fat redistribution 0.058 0 0.042 0 Low Caffeine C0451641 Urolithiasis 0.058 0 0.042 0 Low Caffeine C0240962 Scleral icterus 0.058 0 0.042 0 Low Caffeine C2939103 Perioral paraesthesia 0.058 0 0.042 0 Low Caffeine C0042018 Calculus urinary 0.058 0 0.042 0 Low Caffeine C0265294 Metaphyseal dysplasia 0.057 0 0.087 0 Low Caffeine C0151686 Growth retardation 0.057 0 0.087 0 Low Caffeine C0002888 Anaemia megaloblastic 0.057 0 0.065 0 Low Caffeine C0302870 Microcytic 0.057 0 0.065 0 Low Caffeine C0221265 Microcytosis 0.057 0 0.065 0 Low Caffeine C0004364 Autoimmune disorder 0.057 0 0.065 0 Low Caffeine C1704437 Respiratory distress syndrome 0.057 0 0.065 0 Low Caffeine C0001175 Acquired immunodeficiency syndrome 0.057 0 0.065 0 Low Caffeine C0474381 Chromatopsia 0.057 0 0.065 0 Low Caffeine C0030469 Sinus disorder 0.057 0 0.061 0 Low Caffeine C0011882 Diabetic neuropathy 0.057 0 0.061 0 Low Caffeine C0949691 Spondyloarthropathy 0.057 0 0.061 0 Low Caffeine C0231749 Knee pain 0.057 0 0.061 0 Low Caffeine C0011875 Diabetic vascular disorder 0.057 0 0.061 0 Low Caffeine C0948309 Pseudohyperkalaemia 0.057 0 0.061 0 Low Caffeine C0037933 Spinal disorder 0.057 0 0.061 0 Low Caffeine C0040584 Tracheitis 0.057 0 0.055 0 Low Caffeine C0037286 Neoplasm skin 0.057 0 0.046 0 Low Caffeine C0522757 Exposure to toxic agent 0.057 0 0.045 0 Low Caffeine C0233795 Anterograde amnesia 0.057 0 0.045 0 Low Caffeine C1096444 Altered visual depth perception 0.057 0 0.045 0 Low Caffeine C0239978 Frequent bowel movements 0.057 0 0.045 0 Low Caffeine C0037301 Skin wrinkling 0.057 0 0.045 0 Low Caffeine C0521991 Stress symptoms 0.057 0 0.045 0 Low Caffeine C0027531 Neck injury 0.057 0 0.045 0 Low Caffeine C0853402 Exposure to poisonous plant 0.057 0 0.045 0 Low Caffeine C0596170 Binge eating 0.057 0 0.045 0 Low Caffeine C0022893 Labyrinthitis 0.057 0 0.045 0 Low Caffeine C0007682 Central nervous system disorder 0.056 0 0.085 0 Low Caffeine C0030805 Pemphigoid 0.056 0 0.08 0 Low Caffeine C0853760 Blood potassium increased 0.056 0 0.071 0 Low Caffeine C0040038 Thromboembolism 0.056 0 0.068 0 Low Caffeine C0022658 Nephropathy 0.056 0 0.068 0 Low Caffeine C0340726 Embolism venous 0.056 0 0.068 0 Low Caffeine C0520587 Vulvovaginal discomfort 0.056 0 0.068 0 Low Caffeine C0558368 Vaginal irritation 0.056 0 0.068 0 Low Caffeine C0012359 Distention 0.056 0 0.056 0 Low Caffeine C0035204 Respiratory disorder 0.056 0 0.03 0 Low Caffeine C1260922 Respiration abnormal 0.056 0 0.03 0 Low Caffeine C3665624 Blood calcium decreased 0.055 0 0.098 0 Low Caffeine C0010709 Cyst 0.055 0 0.085 0 Low Caffeine C0852711 Hand and foot syndrome secondary to sickle cell anaemia 0.055 0 0.068 0 Low Caffeine C0549410 Palmar-plantar erythrodysaesthesia syndrome 0.055 0 0.068 0 Low Caffeine C0259756 Jarisch-Herxheimer reaction 0.055 0 0.066 0 Low Caffeine C0160390 Liver injury 0.055 0 0.065 0 Low Caffeine C0018946 Subdural haematoma 0.055 0 0.062 0 Low Caffeine C0155709 Atrial fibrillation and flutter 0.055 0 0.058 0 Low Caffeine C0031190 Persistent foetal circulation 0.055 0 0.058 0 Low Caffeine C1142492 Postinfarction angina 0.055 0 0.058 0 Low Caffeine C0233477 Dysphoria 0.054 0 0.122 0 Low Caffeine C0003635 Apraxia 0.054 0 0.087 0 Low Caffeine C0234131 Motor dysfunction 0.054 0 0.079 0 Low Caffeine C0242656 Disease progression 0.054 0 0.079 0 Low Caffeine C0856054 Mental status changes 0.054 0 0.075 0 Low Caffeine C0009377 Colonic pseudo-obstruction 0.054 0 0.075 0 Low Caffeine C0456909 Blindness 0.054 0 0.065 0 Low Caffeine C0037928 Spinal cord disorder 0.054 0 0.065 0 Low Caffeine C0003708 Arachnoiditis 0.054 0 0.065 0 Low Caffeine C0079744 Diffuse large B-cell lymphoma 0.054 0 0.065 0 Low Caffeine C0600228 Cardio-respiratory arrest 0.054 0 0.065 0 Low Caffeine C0151311 Cranial nerve paralysis 0.054 0 0.065 0 Low Caffeine C0025287 Meningism 0.054 0 0.065 0 Low Caffeine C0034933 Reflexes abnormal 0.054 0 0.065 0 Low Caffeine C0151474 Alcohol intolerance 0.054 0 0.064 0 Low Caffeine C0042487 Venous thrombosis 0.054 0 0.063 0 Low Caffeine C0007758 Cerebellar ataxia 0.054 0 0.063 0 Low Caffeine C0043117 Idiopathic thrombocytopenic purpura 0.054 0 0.063 0 Low Caffeine C0009024 Clonus 0.054 0 0.061 0 Low Caffeine C0349790 Exacerbation of asthma 0.054 0 0.061 0 Low Caffeine C0392703 Shakiness 0.054 0 0.061 0 Low Caffeine C0920166 Catheter site haemorrhage 0.054 0 0.06 0 Low Caffeine C0948824 Haemorrhagic anaemia 0.054 0 0.06 0 Low Caffeine C0855619 Alanine aminotransferase abnormal 0.054 0 0.06 0 Low Caffeine C1696110 Vessel puncture site haematoma 0.054 0 0.06 0 Low Caffeine C1328411 Post procedural haematoma 0.054 0 0.06 0 Low Caffeine C0241558 Urethral haemorrhage 0.054 0 0.06 0 Low Caffeine C0496901 Pituitary tumour benign 0.054 0 0.054 0 Low Caffeine C1384606 Dyspareunia 0.054 0 0.054 0 Low Caffeine C0151511 Breast atrophy 0.054 0 0.054 0 Low Caffeine C0574785 Lower urinary tract symptoms 0.054 0 0.054 0 Low Caffeine C0018500 Hair disorder 0.054 0 0.054 0 Low Caffeine C0032000 Pituitary adenoma 0.054 0 0.054 0 Low Caffeine C0005695 Bladder neoplasm 0.054 0 0.054 0 Low Caffeine C0085129 Bronchial hyperreactivity 0.054 0 0.054 0 Low Caffeine C0029453 Osteopenia 0.054 0 0.052 0 Low Caffeine C0152020 Gastric atony 0.053 0 0.128 0 Low Caffeine C0030517 Parathyroid disorder 0.053 0 0.128 0 Low Caffeine C0522063 Impaired gastric emptying 0.053 0 0.128 0 Low Caffeine C0235893 Allergy aggravated 0.053 0 0.112 0 Low Caffeine C0877094 Application site haemorrhage 0.053 0 0.112 0 Low Caffeine C0007137 Squamous cell carcinoma 0.053 0 0.112 0 Low Caffeine C0854121 Gastrointestinal motility disorder 0.053 0 0.065 0 Low Caffeine C1963818 Gastrointestinal sounds abnormal 0.053 0 0.063 0 Low Caffeine C0159060 Abnormal bowel sounds 0.053 0 0.063 0 Low Caffeine C0162287 Abnormal faeces 0.053 0 0.061 0 Low Caffeine C0003834 Arterial insufficiency 0.053 0 0.057 0 Low Caffeine C0812387 Coldness 0.053 0 0.057 0 Low Caffeine C0239375 Numbness of limbs 0.053 0 0.057 0 Low Caffeine C0038435 Stress 0.053 0 0.057 0 Low Caffeine C0035309 Retinal disorder 0.053 0 0.056 0 Low Caffeine C0011881 Diabetic nephropathy 0.053 0 0.056 0 Low Caffeine Febrile disorders 0.053 0 0.043 0 Low Caffeine Bladder and urethral symptoms 0.053 0 0.043 0 Low Caffeine C0860603 Anxiety symptoms NOS 0.053 0 0.043 0 Low Caffeine C0019372 Herpes virus infection 0.053 0 0.043 0 Low Caffeine C0877096 Application site paraesthesia 0.052 0 0.105 0 Low Caffeine C0022661 Renal failure chronic 0.052 0 0.074 0 Low Caffeine C0024117 Chronic obstructive pulmonary disease 0.052 0 0.055 0 Low Caffeine C0019209 Hepatomegaly 0.052 0 0.037 0 Low Caffeine C0038002 Splenomegaly 0.052 0 0.037 0 Low Caffeine C0151785 Mucous membrane disorder 0.051 0 0.096 0 Low Caffeine C0085166 Vaginitis bacterial 0.051 0 0.093 0 Low Caffeine C2712871 Gout attack 0.051 0 0.083 0 Low Caffeine C0019151 Hepatic encephalopathy 0.051 0 0.083 0 Low Caffeine C0007867 Cervix disorder 0.051 0 0.056 0 Low Caffeine C0743516 Endometrial thickening 0.051 0 0.056 0 Low Caffeine C0525045 Affective disorder 0.051 0 0.035 0 Low Caffeine C0027121 Myositis 0.05 0 0.156 0 Low Caffeine C0542224 Spots before eyes 0.05 0 0.111 0 Low Caffeine C0860967 Calcium low 0.05 0 0.082 0 Low Caffeine C0002390 Alveolitis allergic 0.05 0 0.066 0 Low Caffeine C0854303 Limb discomfort 0.05 0 0.066 0 Low Caffeine C0274702 Cholinergic syndrome 0.05 0 0.066 0 Low Caffeine C3160741 Toxicity to various agents 0.05 0 0.066 0 Low Caffeine C0236151 Renal function test abnormal 0.05 0 0.066 0 Low Caffeine C0029878 Otitis externa 0.05 0 0.065 0 Low Caffeine C0038826 Superinfection 0.049 0 0.071 0 Low Caffeine C0041825 Tympanic membrane disorder 0.049 0 0.063 0 Low Caffeine C0332573 Macule 0.049 0 0.061 0 Low Caffeine C0740304 COPD exacerbation 0.049 0 0.061 0 Low Caffeine C0009144 Tongue coated 0.049 0 0.061 0 Low Caffeine C0235906 Bronchospasm aggravated 0.049 0 0.061 0 Low Caffeine C0429774 Residual urine volume 0.049 0 0.061 0 Low Caffeine C0857160 Numbness in leg 0.049 0 0.061 0 Low Caffeine C0005778 Clotting 0.049 0 0.06 0 Low Caffeine C0009492 Compartment syndrome 0.049 0 0.06 0 Low Caffeine C0239935 Haematocrit increased 0.049 0 0.06 0 Low Caffeine C0558489 Renal pain 0.049 0 0.06 0 Low Caffeine C0853074 Anxiety NEC 0.049 0 0.06 0 Low Caffeine C0020619 Hypogonadism 0.049 0 0.06 0 Low Caffeine C0277986 Gingival oedema 0.049 0 0.06 0 Low Caffeine C0085669 Acute leukaemia 0.049 0 0.06 0 Low Caffeine C0344304 Abdominal pain generalised 0.049 0 0.06 0 Low Caffeine C0026838 Muscle spasticity 0.049 0 0.06 0 Low Caffeine C0162820 Allergic contact dermatitis 0.049 0 0.06 0 Low Caffeine C0877338 Breast discomfort 0.049 0 0.06 0 Low Caffeine C0004930 Behavior disorder 0.049 0 0.06 0 Low Caffeine C0751495 Partial seizures 0.049 0 0.06 0 Low Caffeine C1112469 Cytomegalovirus syndrome 0.049 0 0.06 0 Low Caffeine C2609183 Abnormal withdrawal bleeding 0.049 0 0.06 0 Low Caffeine C1328308 Increased upper airway secretion 0.049 0 0.06 0 Low Caffeine C0221436 Melanoderma 0.049 0 0.06 0 Low Caffeine C0701836 Thermal burn 0.049 0 0.06 0 Low Caffeine C0541974 Fuzzy head 0.049 0 0.06 0 Low Caffeine C0277890 Blood pressure diastolic decreased 0.049 0 0.06 0 Low Caffeine C0919659 Oropharyngeal candidiasis 0.049 0 0.06 0 Low Caffeine C1262141 Poor quality sleep 0.049 0 0.06 0 Low Caffeine C0567085 Uterine pain 0.049 0 0.06 0 Low Caffeine C0039584 Testicular disorder 0.049 0 0.06 0 Low Caffeine C0023467 Acute myeloid leukaemia 0.049 0 0.06 0 Low Caffeine C0162423 Miliaria rubra 0.049 0 0.06 0 Low Caffeine C0221203 Rash vesicular 0.049 0 0.06 0 Low Caffeine C0853019 Blood thyroid stimulating hormone increased 0.049 0 0.06 0 Low Caffeine C0919625 Blood phosphorus increased 0.049 0 0.06 0 Low Caffeine C0403639 Chemical cystitis 0.049 0 0.06 0 Low Caffeine C0009917 Muscle contracture 0.049 0 0.06 0 Low Caffeine C0018989 Hemiparesis 0.049 0 0.06 0 Low Caffeine C0236080 Vaginal discomfort 0.049 0 0.06 0 Low Caffeine C0235324 Gingival swelling 0.049 0 0.06 0 Low Caffeine C0600139 Prostate carcinoma 0.049 0 0.06 0 Low Caffeine C0549201 Asteatosis 0.049 0 0.06 0 Low Caffeine C0427458 Red blood cell count increased 0.049 0 0.06 0 Low Caffeine C0235228 Lacrimal gland disorder 0.049 0 0.06 0 Low Caffeine C1704272 Benign prostatic hyperplasia 0.049 0 0.06 0 Low Caffeine C0270795 Monoparesis 0.049 0 0.06 0 Low Caffeine C0859290 Black spot 0.049 0 0.06 0 Low Caffeine C0006434 Burn 0.049 0 0.06 0 Low Caffeine C0162627 Skin bacterial infection 0.049 0 0.06 0 Low Caffeine C0018818 Ventricular septal defect 0.049 0 0.06 0 Low Caffeine C0877144 Spontaneous penile erection 0.049 0 0.06 0 Low Caffeine C0426390 Bladder spasm 0.049 0 0.06 0 Low Caffeine C0007177 Cardiac tamponade 0.049 0 0.06 0 Low Caffeine C0042755 Virilism 0.049 0 0.06 0 Low Caffeine C0541772 Ammonia increased 0.049 0 0.06 0 Low Caffeine C0948369 Myocardial reinfarction 0.049 0 0.06 0 Low Caffeine C0001125 Lactic acidosis 0.049 0 0.06 0 Low Caffeine C0259768 Wound dehiscence 0.049 0 0.06 0 Low Caffeine C0240735 Personality change 0.049 0 0.06 0 Low Caffeine C1861172 Venous thromboembolism 0.049 0 0.06 0 Low Caffeine C0850149 Dry cough 0.049 0 0.06 0 Low Caffeine C0241729 Weight fluctuation 0.049 0 0.06 0 Low Caffeine C0034530 Radiation injury 0.049 0 0.06 0 Low Caffeine C1096195 Thyroglobulin increased 0.049 0 0.06 0 Low Caffeine C0392039 Ovarian enlargement 0.049 0 0.06 0 Low Caffeine C0853142 CD4 lymphocytes decreased 0.049 0 0.06 0 Low Caffeine C0232602 Retching 0.049 0 0.06 0 Low Caffeine C0240035 Lung fibrosis interstitial 0.049 0 0.06 0 Low Caffeine C0877131 Urinary tract infection fungal 0.049 0 0.06 0 Low Caffeine C1868843 Injection site dryness 0.049 0 0.06 0 Low Caffeine C0235807 Hair texture abnormal 0.049 0 0.06 0 Low Caffeine C0587246 Limb paresis 0.049 0 0.06 0 Low Caffeine C0235763 Psoriasis flare-up 0.049 0 0.06 0 Low Caffeine C1112346 Prostate induration 0.049 0 0.06 0 Low Caffeine C0178415 Prostatic specific antigen increased 0.049 0 0.06 0 Low Caffeine C0018816 Cardiac septal defect 0.049 0 0.06 0 Low Caffeine C0085082 Fungaemia 0.049 0 0.06 0 Low Caffeine C0001622 Hyperadrenocorticism 0.049 0 0.06 0 Low Caffeine C0860851 Oestradiol increased 0.049 0 0.06 0 Low Caffeine C0410256 Muscle injury 0.049 0 0.06 0 Low Caffeine C0238106 Clostridium difficile colitis 0.049 0 0.06 0 Low Caffeine C0007855 Cervical polyp 0.049 0 0.06 0 Low Caffeine C0221264 Cheilosis 0.049 0 0.06 0 Low Caffeine C0242698 Left ventricular dysfunction 0.049 0 0.06 0 Low Caffeine C0235339 Mouth irritation 0.049 0 0.06 0 Low Caffeine C0026113 Miliaria 0.049 0 0.06 0 Low Caffeine C0919823 Cytolytic hepatitis 0.049 0 0.06 0 Low Caffeine C0007166 Cardiac output decreased 0.049 0 0.06 0 Low Caffeine C0553737 Cervical discharge 0.049 0 0.06 0 Low Caffeine C0085635 Photopsia 0.049 0 0.06 0 Low Caffeine C0577730 Family stress 0.049 0 0.06 0 Low Caffeine C0392674 Exhaustion 0.049 0 0.06 0 Low Caffeine C0022116 Ischaemia 0.048 0 0.106 0 Low Caffeine C0239377 Pain in arm 0.048 0 0.086 0 Low Caffeine C0852792 Blood cortisol decreased 0.048 0 0.061 0 Low Caffeine C0740481 Hypotension asymptomatic 0.048 0 0.061 0 Low Caffeine C0008033 Pleuritic pain 0.048 0 0.061 0 Low Caffeine C0860645 Bizarre dreams 0.048 0 0.061 0 Low Caffeine C0852928 Insomnia exacerbated 0.048 0 0.043 0 Low Caffeine C0016169 Fistula 0.048 0 0.042 0 Low Caffeine C0235304 Acid indigestion 0.048 0 0.042 0 Low Caffeine C0034103 Pulpitis dental 0.048 0 0.042 0 Low Caffeine C0011432 Sensitivity of teeth 0.048 0 0.042 0 Low Caffeine C0376356 Premenstrual tension 0.048 0 0.042 0 Low Caffeine C0040441 Tooth fracture 0.048 0 0.042 0 Low Caffeine C0024031 Low back pain 0.048 0 0.042 0 Low Caffeine C0239739 Gingival pain 0.048 0 0.042 0 Low Caffeine C0857183 Pre-menstrual tension syndrome 0.048 0 0.042 0 Low Caffeine C0080233 Tooth loss 0.048 0 0.042 0 Low Caffeine C0031024 Dentoalveolar abscess 0.048 0 0.042 0 Low Caffeine C0236993 Other sleep disturbances 0.048 0 0.036 0 Low Caffeine C1264613 Gastrointestinal infection 0.048 0 0.036 0 Low Caffeine C0596601 Gas 0.048 0 0.036 0 Low Caffeine C0744727 Haematocrit decreased 0.047 0 0.098 0 Low Caffeine C0043241 Wound infection 0.047 0 0.065 0 Low Caffeine C0018824 Cardiac valve disease 0.046 0 0.068 0 Low Caffeine C0857483 Worsening of diabetes 0.046 0 0.068 0 Low Caffeine C1112209 Abdominal infection 0.046 0 0.051 0 Low Caffeine C0019054 Haemolysis 0.046 0 0.051 0 Low Caffeine C0008350 Cholelithiasis 0.045 0 0.092 0 Low Caffeine C2939419 Metastatic neoplasm 0.045 0 0.087 0 Low Caffeine C0858678 Alopecia reversible 0.045 0 0.081 0 Low Caffeine C1142172 Incision site complication 0.045 0 0.047 0 Low Caffeine Gastrointestinal inflammatory conditions 0.045 0 0.047 0 Low Caffeine C0019345 Herpes labialis 0.045 0 0.047 0 Low Caffeine C0008370 Cholestasis 0.045 0 0.047 0 Low Caffeine Vascular hypotensive disorders 0.045 0 0.047 0 Low Caffeine Paraesthesias and dysaesthesias 0.045 0 0.047 0 Low Caffeine C1141861 Procedural complication 0.045 0 0.047 0 Low Caffeine C0852908 Drug ineffective 0.045 0 0.047 0 Low Caffeine Polyomavirus infections 0.045 0 0.047 0 Low Caffeine C0948031 Primary graft dysfunction 0.045 0 0.047 0 Low Caffeine Bile duct disorders 0.045 0 0.047 0 Low Caffeine C0584995 Writing impaired 0.045 0 0.047 0 Low Caffeine C0234144 Dysgraphia 0.045 0 0.047 0 Low Caffeine C0740380 Varicella zoster 0.045 0 0.047 0 Low Caffeine Gastrointestinal signs and symptoms 0.045 0 0.047 0 Low Caffeine C1167870 Graft dysfunction 0.045 0 0.047 0 Low Caffeine C0151810 Lack of drug effect 0.045 0 0.047 0 Low Caffeine C0858794 Application site warmth 0.045 0 0.047 0 Low Caffeine C0936250 Eczema herpeticum 0.045 0 0.047 0 Low Caffeine C0858346 Gastrointestinal ulcer perforation 0.045 0 0.047 0 Low Caffeine C0022504 Kaposi's varicelliform eruption 0.045 0 0.047 0 Low Caffeine Ischaemic coronary artery disorders 0.045 0 0.047 0 Low Caffeine C0858797 Instillation site pain 0.044 0 0.21 0 Low Caffeine C1699324 Pharyngeal mucositis 0.044 0 0.115 0 Low Caffeine C0877584 Tumour haemorrhage 0.044 0 0.115 0 Low Caffeine C0221406 Pituitary-dependent Cushing's syndrome 0.044 0 0.088 0 Low Caffeine C0239940 Glycosylated haemoglobin increased 0.044 0 0.088 0 Low Caffeine C0011860 Type 2 diabetes mellitus 0.044 0 0.088 0 Low Caffeine C0860801 Glucose low 0.044 0 0.058 0 Low Caffeine C0033778 Pruritus vulvae 0.043 0 0.082 0 Low Caffeine C0151563 Coagulation time prolonged 0.043 0 0.075 0 Low Caffeine C0023510 White blood cell disorder 0.043 0 0.075 0 Low Caffeine C0040128 Thyroid disorder 0.043 0 0.075 0 Low Caffeine C0152009 WBC abnormal NOS 0.043 0 0.075 0 Low Caffeine C0235527 Cardiac failure right 0.043 0 0.075 0 Low Caffeine C0221269 Pseudolymphoma 0.043 0 0.075 0 Low Caffeine C0853697 Neutrophil count decreased 0.042 0 0.128 0 Low Caffeine C0856088 Constipation aggravated 0.042 0 0.057 0 Low Caffeine C0041296 Tuberculosis 0.041 0 0.063 0 Low Caffeine C0428886 Mean arterial pressure 0.041 0 0.062 0 Low Caffeine C0011334 Dental caries 0.041 0 0.059 0 Low Caffeine C0023532 Leukoplakia oral 0.041 0 0.059 0 Low Caffeine C0595885 Serum potassium decreased 0.041 0 0.055 0 Low Caffeine C0243001 Abdominal abscess 0.041 0 0.055 0 Low Caffeine C0235329 Small intestinal obstruction 0.041 0 0.055 0 Low Caffeine C0278061 Mental state abnormal 0.041 0 0.055 0 Low Caffeine C1868855 Post procedural infection 0.041 0 0.055 0 Low Caffeine C0392618 Postoperative infection 0.041 0 0.055 0 Low Caffeine C0553704 Serum potassium increased 0.041 0 0.055 0 Low Caffeine C0580493 Serum albumin decreased 0.041 0 0.055 0 Low Caffeine C0011974 Dermatitis diaper 0.041 0 0.055 0 Low Caffeine C1096106 Wound complication 0.041 0 0.055 0 Low Caffeine C0859062 Serum bilirubin increased 0.041 0 0.055 0 Low Caffeine C0521496 Application site infection 0.039 0 0.077 0 Low Caffeine C2718128 Nasal inflammation 0.039 0 0.059 0 Low Caffeine C3495832 Rheumatic disorder 0.039 0 0.059 0 Low Caffeine C0035435 Rheumatism 0.039 0 0.059 0 Low Caffeine C0553702 Ca++ increased 0.038 0 0.075 0 Low Caffeine C2939447 Right ventricular failure 0.037 0 0.085 0 Low Caffeine C0162275 Ketonuria 0.036 0 0.131 0 Low Caffeine C0020492 Hyperostosis 0.036 0 0.131 0 Low Caffeine C0861157 Decreased night vision 0.036 0 0.131 0 Low Caffeine C0028077 Night blindness 0.036 0 0.131 0 Low Caffeine C0041981 Uric acid level increased 0.036 0 0.131 0 Low Caffeine C1442903 Exostosis 0.036 0 0.131 0 Low Caffeine C0033845 Benign intracranial hypertension 0.036 0 0.131 0 Low Caffeine C0859978 Amylase decreased 0.036 0 0.079 0 Low Caffeine C0595879 Sodium high 0.036 0 0.079 0 Low Caffeine C0595878 Blood sodium increased 0.036 0 0.079 0 Low Caffeine C0043167 Pertussis 0.031 0 0.065 0 Low Caffeine C0031085 Abscess periodontal 0.025 0 0.05 0 Low # Start Time: Nov 13 2018 19:26:12 # End Time: Nov 13 2018 19:33:47