Brief Introduction

A side effect is usually regarded as an undesirable secondary effect which occurs in addition to the desired therapeutic effect of a drug or medication. They are phenotypic responses of the human organism to drug treatment. At present, regulatory guidelines require extensive in vivo studies which refer to safety pharmacology. However, these studies are costly and time demanding and most importantly they enter the project flowcharts at late stages and with low capacity. Therefore, side effects have become an important subject of research in the pharmaceutical industry. Pharmaceutical company are interested in predicting the possible side effects of drug candidates at early stage of drug development.

In this project, we developed a web server called Drug Side-Effect Predictor for predicting side effect of given compounds or drugs. The web server is rapid and accurate (Accuracy > 90% and AUC > 0.90), which enables us to identify the possible side effects of the candidate compounds.